guest ::
| Home > Articles > Published articles > A baseline metabolomic signature is associated with immunological CD4 + T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients |
| Home > Articles > Published articles > A baseline metabolomic signature is associated with immunological CD4 + T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients |
(Hospital Universitari Joan XXIII de Tarragona) (Hospital Universitari Joan XXIII de Tarragona) (Hospital Universitari Joan XXIII de Tarragona) (Hospital Universitari Joan XXIII de Tarragona) (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) (Hospital Universitari Joan XXIII de Tarragona) (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica, Elèctrica i Automàtica) (Institut d'Investigació Biomèdica Sant Pau) (Hospital Universitari Joan XXIII de Tarragona)| Date: | 2018 |
| Abstract: | Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. We aimed to identify a baseline metabolomic signature associated with a poor immunological recovery after antiretroviral therapy (ART) to envisage the underlying mechanistic pathways that influence the treatment response. This was a multicentre, prospective cohort study in ART-naive and a pre-ART low nadir (<200 cells/μl) HIV-infected patients (n = 64). We obtained clinical data and metabolomic profiles for each individual, in which low molecular weight metabolites, lipids and lipoproteins (including particle concentrations and sizes) were measured by NMR spectroscopy. Immunological recovery was defined as reaching CD4 + T-cell count at least 250 cells/μl after 36 months of virologically successful ART. We used univariate comparisons, Random Forest test and receiver-operating characteristic curves to identify and evaluate the predictive factors of immunological recovery after treatment. HIV-infected patients with a baseline metabolic pattern characterized by high levels of large high density lipoprotein (HDL) particles, HDL cholesterol and larger sizes of low density lipoprotein particles had a better immunological recovery after treatment. Conversely, patients with high ratios of non-HDL lipoprotein particles did not experience this full recovery. Medium very-low-density lipoprotein particles and glucose increased the classification power of the multivariate model despite not showing any significant differences between the two groups. In HIV-infected patients, a baseline healthier metabolomic profile is related to a better response to ART where the lipoprotein profile, mainly large HDL particles, may play a key role. |
| Grants: | Instituto de Salud Carlos III FIS/PI10/02635 Instituto de Salud Carlos III FIS/PI13/00796 Instituto de Salud Carlos III FIS/PI13/01912 Instituto de Salud Carlos III FIS/PI14/0700 Instituto de Salud Carlos III FIS/PI14/0063 Instituto de Salud Carlos III FIS/PI14/01693 Instituto de Salud Carlos III FIS/PI16/00503 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR250 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009SGR1061 Instituto de Salud Carlos III RIS/RD12-0017-0002 Instituto de Salud Carlos III RIS/RD12-0017-0005 Instituto de Salud Carlos III RIS/RD12-0017-0014 Instituto de Salud Carlos III RIS/RD12-0017/0029 Instituto de Salud Carlos III RIS/RD16-0025-0006 Instituto de Salud Carlos III INT11-240 Instituto de Salud Carlos III INT12-282 Instituto de Salud Carlos III INT12-383 Instituto de Salud Carlos III INT13-232 Instituto de Salud Carlos III INT15-226 Instituto de Salud Carlos III INT15-140 Instituto de Salud Carlos III FIS/cpii13/00037 |
| Note: | Altres ajuts: GLD13/00168 |
| Note: | Altres ajuts: GLD14/293 |
| Note: | Altres ajuts: PERIS/SLT002-16-00101 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Antiretroviral therapy ; Biomarkers ; HIV-1 ; Metabolomics ; Poor immune recovery |
| Published in: | AIDS, Vol. 32 (march 2018) , p. 565-573, ISSN 1473-5571 |
