Beyond molecular tumor heterogeneity : protein synthesis takes control
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hümmer, Stefan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pelletier, Jerry (Montreal, QC Canada)
Sonenberg, Nahum (Montreal, QC Canada)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	One of the daunting challenges facing modern medicine lies in the understanding and treatment of tumor heterogeneity. Most tumors show intra-tumor heterogeneity at both genomic and proteomic levels, with marked impacts on the responses of therapeutic targets. Therapeutic target-related gene expression pathways are affected by hypoxia and cellular stress. However, the finding that targets such as eukaryotic initiation factor (eIF) 4E (and its phosphorylated form, p-eIF4E) are generally homogenously expressed throughout tumors, regardless of the presence of hypoxia or other cellular stress conditions, opens the exciting possibility that malignancies could be treated with therapies that combine targeting of eIF4E phosphorylation with immune checkpoint inhibitors or chemotherapy.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014, 1131
Note:	Altres ajuts: 245 SRYC acknowledges support from Fondo de Investigaciones Sanitarias (P1170185 and PI 14/01320), Redes Temáticas de Investigación Cooperativa en Salud (RTICC, RD 12/0036/0057), and CIBERONC 2017.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Oncogene, Vol. 37 (february 2018) , p. 2490-2501, ISSN 1476-5594

DOI: 10.1038/s41388-018-0152-0
PMID: 29463861

12 p, 4.3 MB

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