Long-term dynamics of Mycoplasma conjunctivae at the wildlife-livestock interface in the Pyrenees
Fernández Aguilar, Xavier (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Frey, Joachim (University of Bern. Institute of Veterinary Bacteriology)
Velarde, Roser (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Serrano Ferron, Emmanuel (Universidad de Aveiro . Departamento de Biologia and Cesam)
Colom Cadena, Andreu (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Gelormini, Giuseppina (University of Bern. Institute of Veterinary Bacteriology)
Marco, Ignasi (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Mentaberre García, Gregorio (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Lavín González, Santiago (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
López Olvera, Jorge R. (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Cabezón Ponsoda, Óscar (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)

Fecha:	2017
Resumen:	Functional roles of domestic and wild host populations in infectious keratoconjunctivitis (IKC) epidemiology have been extensively discussed claiming a domestic reservoir for the more susceptible wild hosts, however, based on limited data. With the aim to better assess IKC epidemiology in complex host-pathogen alpine systems, the long-term infectious dynamics and molecular epidemiology of Mycoplasma conjunctivae was investigated in all host populations from six study areas in the Pyrenees and one in the Cantabrian Mountains (Northern Spain). Detection of M. conjunctivae was performed by qPCR on 3600 eye swabs collected during seven years from hunted wild ungulates and sympatric domestic sheep (n = 1800 animals), and cluster analyses of the strains were performed including previous reported local strains. Mycoplasma conjunctivae was consistently detected in three Pyrenean chamois (Rupicapra p. pyrenaica) populations, as well as in sheep flocks (17. 0% of sheep) and occasionally in mouflon (Ovis aries musimon) from the Pyrenees (22. 2% in one year/area); statistically associated with ocular clinical signs only in chamois. Chamois populations showed different infection dynamics with low but steady prevalence (4. 9%) and significant yearly fluctuations (0. 0%- 40. 0%). Persistence of specific M. conjunctivae strain clusters in wild host populations is demonstrated for six and nine years. Cross-species transmission between chamois and sheep and chamois and mouflon were also sporadically evidenced. Overall, independent M. conjunctivae sylvatic and domestic cycles occurred at the wildlife-livestock interface in the alpine ecosystems from the Pyrenees with sheep and chamois as the key host species for each cycle, and mouflon as a spill-over host. Host population characteristics and M. conjunctivae strains resulted in different epidemiological scenarios in chamois, ranging from the fading out of the mycoplasma to the epidemic and endemic long-term persistence. These findings highlight the capacity of M. conjunctivae to establish diverse interactions and persist in host populations, also with different transmission conditions.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Animals ; Domestic animals ; Wild animals ; Host-Pathogen Interactions ; Keratoconjunctivitis ; Livestock ; Mycoplasma conjunctivae ; Mycoplasma Infections ; Rupicapra ; Sheep ; Sheep Diseases ; Spain
Publicado en:	PloS one, Vol. 12 Núm. 10 (october 2017) , p. e0186069, ISSN 1932-6203

DOI: 10.1371/journal.pone.0186069
PMID: 29016676

18 p, 10.4 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
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