Fixation of light weight polypropylene mesh with n-butyl-2-cyanocrylate in pelvic floor surgery : Experimental design approach in sheep for effectiveness evaluation
Barbosa Perez, Sandra (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Nieves, Tania (B. Braun Surgical S.A.)
García Arnas, Félix (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Cepeda, Eva (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Marco Valle, Alberto (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Weis, Christine (B. Braun Surgical S.A.)
Turon, Pau (B. Braun Surgical S.A.)
Vergara, Patri (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Data: |
2015 |
Resum: |
Objective. The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate (Histoacryl) as a fixation method for a light-weight and large pore PP mesh (Synthetic PP Mesh-1) using the sheep as an animal model. Methods. Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated macroscopically and histologically at 3 months (n = 4) and 6 months (n = 4) post-surgery. In previous pilot studies anterior vaginal implantation was evaluated, as well as different synthetic mesh materials, sizes and fixation methods (n = 1 to 3) during three weeks. In all cases a clinical evaluation of the animal was performed. Results. A reduction in the mesh size (Synthetic PP Mesh-1) together with precise application of the surgical glue Histoacryl to fix the mesh yielded significantly better histocompatibility results (P < 0. 01) compared to larger size or other fixation methods. Conclusion. The combination of Synthetic PP Mesh-1 with Histoacryl offered a high degree of graft integration without vaginal ulceration and a minimal foreign body reaction, being the sheep a proper animal model to test these types of medical devices. |
Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Animals ;
Enbucrilate ;
Episiotomy ;
Female ;
Humans ;
Models, Animal ;
Pelvic Floor ;
Sheep ;
Surgical Mesh ;
Vagina |
Publicat a: |
BioMed Research International, Vol. 2015 (2015) , art. 737683, ISSN 2314-6141 |
DOI: 10.1155/2015/737683
PMID: 26221605
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