Underdosing of Surfactant for Preterm Babies with Respiratory Distress Syndrome in Clinical Practice : A Retrospective Cohort Study
Boix, Hector (Hospital Universitari Vall d'Hebron)
Rite, Segundo (Hospital Universitario Miguel Servet (Saragossa))
Arruza, Luis (Hospital Clínico San Carlos (Madrid))
Fernández, Cristina (Hospital Universitari Vall d'Hebron)
Serrano, Itziar (Hospital Universitario Miguel Servet (Saragossa))
Baquedano, Irene (Hospital Universitario Miguel Servet (Saragossa))
Sanchez, Ana (Hospital Universitario La Paz (Madrid))
Ferreira, Erika (Hospital Universitario La Paz (Madrid))
Fernandez, Patricia (Hospital Clínico San Carlos (Madrid))
Gonzalez, Rosa (Hospital Clínico San Carlos (Madrid))
Elorza, M. Dolores (Hospital Universitario La Paz (Madrid))
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Objective: To evaluate the initial doses of surfactant administered to preterm infants with respiratory distress syndrome. Study Design: This is a retrospective cohort study of 206 preterm infants admitted in four level III neonatal intensive care units of acute tertiary care hospitals in Spain between 2013 and 2015. Results: The mean initial dose of surfactant was 173. 9 (37. 3) mg/kg, and 47. 5% of infants received a dose of 200 mg/kg ± 10% (180-220 mg/kg), 47% less than 180 mg/kg (-10%), and 5. 4% more than 220 mg/kg (+10%). Very preterm infants (<28 weeks) received higher initial doses than more mature infants, but in all cases, the mean doses were below the recommended 200 mg/kg (by 9. 2% in gestational age 23-28 weeks, by 15. 9% in 29-32 weeks, and by 24. 3% in >32 weeks). Conclusion: Administration of surfactant below the prescribed dose is a frequent error in clinical practice. Inadvertently rounding down doses seems a plausible explanation.
Nota:	This study was supported by Chiesi España, S.A.U., Barcelona, Spain.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Estudi clínic ; recerca ; Versió publicada
Matèria:	Dosage ; Preterm babies ; Respiratory distress syndrome ; Surfactant
Publicat a:	American Journal of Perinatology, Vol. 36 Núm. 9 (2019) , p. 943-948, ISSN 1098-8785

DOI: 10.1055/s-0038-1675645

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