Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin : educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)
Saenger, Amy K. (University of Minnesota. Department of Laboratory Medicine and Pathology)
Jaffe, Allan S. (Mayo Clinic. Department of Laboratory Medicine and Pathology and Cardiology)
Body, Richard (Manchester University NHS Foundation Trust. Healthcare Sciences Department)
Collinson, Paul O. (St George's University Hospitals NHS Foundation Trust. Department of Clinical Blood Sciences and Cardiology)
Kavsak, Peter A. (McMaster University. Department of Pathology and Molecular Medicine)
Lam, Carolyn S. P. (Duke-National University of Singapore)
Lefèvre, Guillaume (Hospital Tenon. Service de Biochimie-Hormonologie)
Omland, Tobjørn (Akershus University Hospital)
Ordoñez Llanos, Jorge 1952- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Pulkki, Kari (University of Turku. Department of Clinical Chemistry)
Apple, Fred S. (University of Minnesota. Department of Laboratory Medicine and Pathology)

Date:	2019
Abstract:	Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation.
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biotin ; Hemolysis ; Interferences ; Natriuretic ; Peptide ; Troponin
Published in:	Clinical Chemistry and Laboratory Medicine, Vol. 57, issue 5 (2019) , p. 633-640, ISSN 1437-4331

DOI: 10.1515/cclm-2018-0905
PMID: 30291783

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