Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study
So-Armah, Kaku (Boston University School of Medicine. Department of Medicine)
Freiberg, Matthew (Vanderbilt University School of Medicine; Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System. Department of Medicine)
Cheng, Debbie (Boston University School of Public Health. Department of Biostatistics)
Lim, Joseph K. (Yale University School of Medicine. Department of Internal Medicine)
Gnatienko, Natalia (Boston Medical Center. Department of Medicine)
Patts, Gregory (Boston University School of Public Health. Department of Biostatistics and Data Coordinating Center)
Doyle, Margaret (University of Vermont. Department of Pathology and Laboratory Medicine)
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lioznov, Dmitry (First Pavlov State Medical University. Department of Infectious Diseases and Epidemiology, Smorodintsev Research Institute of Influenza)
Krupitsky, Evgeny (First Pavlov State Medical University, V. M. Bekhterev National Research Medical Center for Psychiatry and Neurology, St. Petersburg, Russia)
Samet, Jeffrey (Boston University School of Medicine. Department of Medicine, Boston Medical Center)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, may be accentuated in HIV and leads to poor outcomes. The liver regulates innate immunity and adaptive immune tolerance. HIV-infected people have high prevalence of liver-related comorbidities. We hypothesize that advanced liver fibrosis/cirrhosis is associated with alterations in T-cell subsets consistent with immunosenescence. ART-naïve people with HIV with a recent history of heavy drinking were recruited into a clinical trial of zinc supplementation. Flow cytometry was used to characterize T-cell subsets. The two primary dependent variables were CD8+ and CD4+ T-cells expressing CD28-CD57+ (senescent cell phenotype). Secondary dependent variables were CD8+ and CD4+ T-cells expressing CD45RO + CD45RA- (memory phenotype), CD45RO-CD45RA+ (naïve phenotype), and the naïve phenotype to memory phenotype T-cell ratio (lower ratios associated with immunosenescence). Advanced liver fibrosis/cirrhosis was defined as FIB-4 > 3. 25, APRI≥1. 5, or Fibroscan measurement ≥10. 5 kPa. Analyses were conducted using multiple linear regression adjusted for potential confounders. Mean age was 34 years; 25% female; 88% hepatitis C. Those with advanced liver fibrosis/cirrhosis (N = 25) had higher HIV-1 RNA and more hepatitis C. Advanced liver fibrosis/cirrhosis was not significantly associated with primary or secondary outcomes in adjusted analyses. Advanced liver fibrosis/cirrhosis was not significantly associated with these senescent T-cell phenotypes in this exploratory study of recent drinkers with HIV. Future studies should assess whether liver fibrosis among those with HIV viral suppression and more advanced, longstanding liver disease is associated with changes in these and other potentially senescent T-cell subsets.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HIV ; Liver fibrosis ; Immune senescence ; Russia ; Alcohol
Published in:	BMC Gastroenterology, Vol. 20 (december 2019) , ISSN 1471-230X

DOI: 10.1186/s12876-019-1136-4
PMID: 31892306

8 p, 518.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles