Mephedrone and Alcohol Interactions in Humans
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
de Sousa Fernandes Perna, Elizabeth B.. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University)
Olesti, Eulàlia (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Mateus, Julian (Institut Hospital del Mar d'Investigacions Mèdiques)
Kuypers, Kim P. C. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University)
Theunissen, Eef L. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University)
Fonseca, Francina, 1972- (Institut Hospital del Mar d'Investigacions Mèdiques)
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Ramaekers, Jan G. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University)
De La Torre, Rafael (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Data:	2020
Resum:	Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly used simultaneously with alcohol (ethanol). The aim of the present study was to evaluate the interactions on subjective, cardiovascular and hormone effects and pharmacokinetics between mephedrone and alcohol in humans. Eleven male volunteers participated as outpatients in four experimental sessions in a double-blind, randomized, cross-over, and placebo-controlled clinical trial. Participants received a single oral dose of 200 mg of mephedrone plus 0. 8 g/kg of alcohol (combination condition); 200 mg of mephedrone plus placebo alcohol (mephedrone condition); placebo mephedrone plus 0. 8 g/kg of ethanol (alcohol condition); and placebo mephedrone plus placebo alcohol (placebo condition). Outcome variables included physiological (blood pressure, heart rate, temperature, and pupil diameter), psychomotor (Maddox wing), subjective (visual analogue scales, Addiction Research Center Inventory 49 item short form, and Valoración de los Efectos Subjetivos de Sustancias con Potencial de Abuso questionnaire), and pharmacokinetic parameters (mephedrone and ethanol concentrations). The study was registered in ClinicalTrials. gov, number NCT02294266. The mephedrone and alcohol combination produced an increase in the cardiovascular effects of mephedrone and induced a more intense feeling of euphoria and well-being in comparison to the two drugs alone. Mephedrone reduced the sedative effects produced by alcohol. These results are similar to those obtained when other psychostimulants such as amphetamines and 3,4-methylenedioxymethamphetamine are combined simultaneously with alcohol. The abuse liability of mephedrone combined with alcohol is greater than that induced by mephedrone alone.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Frontiers in Pharmacology, Vol. 10 (january 2020) , ISSN 1663-9812

DOI: 10.3389/fphar.2019.01588
PMID: 32063845

17 p, 1.4 MB

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