Risk factors for mortality in elderly and very elderly critically ill patients with sepsis : a prospective, observational, multicenter cohort study
Martin-Loeches, Ignacio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Guia, Maria Consuelo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Vallecoccia, Maria Sole (Università Cattolica del Sacro Cuore - Fondazione Policlinico Universitario A.Gemelli. Department of Intensive Care and Anaesthesiology)
Suarez, David (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ibarz, Mercedes (Hospital del Sagrat Cor (Barcelona, Catalunya))
Irazabal, Marian (Hospital del Sagrat Cor (Barcelona, Catalunya))
Ferrer, Ricard (Hospital Universitari Vall d'Hebron)
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Age has been traditionally considered a risk factor for mortality in elderly patients admitted to intensive care units. The aim of this prospective, observational, multicenter cohort study is to determine the risk factors for mortality in elderly and very elderly critically ill patients with sepsis. A total of 1490 patients with ≥ 65 years of age were included in the study; most of them 1231 (82. 6%) had a cardiovascular failure. The mean age (± SD) was 74. 5 (± 5. 6) years, and 876 (58. 8%) were male. The patients were divided into two cohorts: (1) elderly: 65-79 years and (2) very elderly: ≥ 80 years. The overall hospital mortality was 48. 8% (n = 727) and was significantly higher in very elderly compared to elderly patients (54. 2% vs. 47. 4%; p = 0. 02). Factors independently associated with mortality were APACHE II score of the disease, patient location at sepsis diagnosis, development of acute kidney injury, and thrombocytopenia in the group of elderly patients. On the other hand, in the group of very elderly patients, predictors of hospital mortality were age, APACHE II score, and prompt adherence of the resuscitation bundle. This prospective multicenter study found that patients aged 80 or over had higher hospital mortality compared to patients between 65 and 79 years. Age was found to be an independent risk factor only in the very elderly group, and prompt therapy provided within the first 6 h of resuscitation was associated with a reduction in hospital mortality in the very elderly patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Elderly ; Aging ; ICU ; Sepsis ; Septic shock ; Bundles ; Critical care
Published in:	Annals of Intensive Care, Vol. 9 (february 2019) , ISSN 2110-5820
Related work:	Martin-Loeches, Ignacio; Guia, Maria Consuelo; Vallecoccia, Maria Sole; [et al.]. «Correction to: Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study». Annals of Intensive Care, Vol. 9 (march 2019), p.1 https://doi.org/10.1186/s13613-019-0495-x

Correcció de l'article: https://ddd.uab.cat/record/253260
DOI: 10.1186/s13613-019-0495-x
PMID: 30715638

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Articles > Published articles