Effectiveness and cost-effectiveness of a multicomponent intervention to improve medication adherence in people with depressive disorders - MAPDep : a study protocol for a cluster randomized controlled trial
del Pino-Sedeño, Tasmania (Universidad de La Laguna)
Peñate, Wenceslao (Universidad de La Laguna)
de las Cuevas, Carlos (Universidad de La Laguna)
Valcarcel-Nazco, Cristina (Universidad de La Laguna)
Fumero, Ascensión (Universidad de La Laguna)
Serrano-Pérez, Pedro (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Acosta Artiles, Francisco Javier (Service of Mental Health, General Health Care Programs Direction, Canary Health Service, Las Palmas de Gran Canaria)
Ramos García, Vanesa (Canary Islands Foundation of Health Research)
León Salas, Beatriz (Canary Islands Foundation of Health Research)
Bejarano-Quisoboni, Daniel (Center for Public Health Research, València)
Trujillo-Martín, María (Canary Islands Foundation of Health Research)

Data:	2019
Resum:	Depression is a widespread mental disorder which can be treated effectively. However, low adherence to antidepressants is very common. The study of medication adherence in depression (MAPDep study) assesses the effectiveness and cost-effectiveness of a multicomponent strategy to enhance adherence toward medications in patients with depression. The intervention is a multicomponent one consisting of an educational program for psychiatrists and/or a collaborative care program for patients and relatives, plus a reminder system that works through the use of an already available high-quality medication reminder application. MAPDep study is an open, multicenter, four-arm cluster randomized controlled trial. The clusters are mental health units where psychiatrists are invited to participate. The clusters are randomly allocated to one of the three interventions or to usual care (control arm). Patients (18-65 years of age) diagnosed with depressive disorder, those taking antidepressant medication for an existing diagnosis of depression, and mobile phone users are selected. In group 1, only patients and relatives receive intervention; in group 2, only psychiatrists receive intervention; and in group 3, patients/relatives and psychiatrists receive intervention. The primary outcome is adherence to the antidepressant drug. The calculated sample size is 400 patients. To examine changes across time, generalized linear mixed model with repeated measures will be used. A cost-effectiveness analysis will be conducted. The effectiveness measure is quality-adjusted life years. Deterministic sensitivity analyses are planned. MAPDep study aims to assess a multicomponent strategy to improve adherence toward medications in patients with depression, based not only on clinical effectiveness but also on cost-effectiveness. This methodology will enhance the transferability of the expected results beyond mental health services (patients and psychiatrists) to health care policy decision making. NCT03668457.
Ajuts:	Instituto de Salud Carlos III PI18/00767
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Depression ; Medication adherence ; Education ; Behavior modification ; Mobile phone technology ; Cost-effectiveness
Publicat a:	Patient preference and adherence, Vol. 13 (february 2019) , p. 309-319, ISSN 1177-889X

DOI: 10.2147/PPA.S172963
PMID: 30863020

11 p, 389.8 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats