Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults
Pérez, Laura Mónica (Hospital Universitari Vall d'Hebron)
Hooshmand, Babak (Ulleval University Hospital (Norway))
Mangialasche, Francesca (Karolinska Institutet (Estocolm, Suècia))
Mecocci, Patrizia (University of Perugia)
Smith, A. David (Department of Pharmacology, University of Oxford)
Refsum, Helga (University of Oslo)
Inzitari, Marco (Universitat Autònoma de Barcelona. Departament de Medicina)
Fratiglioni, Laura (Stockholm Gerontology Research Center)
Rizzuto, Debora (Stockholm University)
Calderón-Larrañaga, Amaia (Stockholm University)

Date:	2019
Abstract:	We aimed to investigate the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time. The study population (n = 2,596) was derived from a population-based longitudinal study on ≥60-year-olds living in Stockholm. Participants were clinically assessed at baseline, 3- and 6-year follow-ups. Multimorbidity was measured as the number of chronic conditions from a previously built list of 60 diseases. Linear mixed models were applied to analyze the association between baseline tGSH levels and the rate of multimorbidity development over 6 years. We found that at baseline, participants with ≥4 diseases had lower tGSH levels than participants with no chronic conditions (3. 3 vs 3. 6 µmol/L; p <. 001). At follow-up, baseline levels of tGSH were inversely associated with the rate of multimorbidity development (β * time: −0. 044, p <. 001) after adjusting for age, sex, education, levels of serum creatinine, C-reactive protein, albumin, body mass index, smoking, and time of dropout or death. In conclusion, serum levels of tGSH are inversely associated with multimorbidity development; the association exists above and beyond the link between tGSH and specific chronic conditions. Our findings support the hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Multimorbidity ; Epidemiology ; Biogerontology
Published in:	The journals of gerontology, Vol. 75 (april 2019) , p. 1089-1094, ISSN 1758-535X

DOI: 10.1093/gerona/glz101
PMID: 31086967

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