Nerve-sparing versus non-nerve-sparing radical hysterectomy : surgical and long-term oncological outcomes
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron)
Carbonell-Socias, Melchor (Hospital Universitari Vall d'Hebron)
Salicrú, Sabina (Hospital Universitari Vall d'Hebron)
Bradbury, Melissa (Hospital Universitari Vall d'Hebron)
García, Ángel (Hospital Universitari Vall d'Hebron)
Vergés, Ramona (Hospital Universitari Vall d'Hebron)
Puig, Oriol Puig (Hospital Universitari Vall d'Hebron)
Sánchez-Iglesias, José Luís (Hospital Universitari Vall d'Hebron)
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
de la Torre, Javier (Hospital Universitari Vall d'Hebron)
Gómez-Hidalgo, Natalia R. (Hospital Universitari Vall d'Hebron)
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron)
Díaz-Feijoo, Berta (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	There are controversies regarding the long-term oncological safety of preservation of pelvic innervation during radical hysterectomy (RH). This study aimed to analyze the feasibility and safety of nerve-sparing radical hysterectomy (NSRH) for cervical cancer compared with non-NSRH following 17 years of experience in a tertiary cancer referral center. Between May 1999 and June 2016, all patients who underwent RH for cervical cancer were followed-up prospectively. Comparison analyses regarding surgical outcomes, complications, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were performed between patients treated with NSRH and non-NSRH. A total of 188 patients were included (113 non-NSRH and 75 NSRH). The median follow-up was 112 months. Estimated blood loss and hospital stay were all significantly lower in the NSRH group. Overall intraoperative complication rate (p = 0. 02) and need for transfusion (p = 0. 016) were lower in the NSRH group. There were no differences in the median operation time, OS, DFS, CSS, or recurrence rates between the NSRH and non-NSRH group. Our study provides a wide perspective on the developments of nerve-sparing procedures for the management of women with early-stage cervical cancer. Our results suggest that NSRH is a feasible and safe procedure, with reduced morbidity outcomes.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cervical cancer ; Morbidity ; Recurrence ; Surgical treatment ; Survival
Published in:	Oncotarget, Vol. 10 (july 2019) , p. 4598-4608, ISSN 1949-2553

DOI: 10.18632/oncotarget.27078
PMID: 31360307

11 p, 3.2 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles