Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) : Gender-specific changes in the microRNA expression profiling in ME/CFS
Cheema, Amanpreet K. (Nova Southeastern University)
Sarria, Leonor (Nova Southeastern University)
Bekheit, Mina (Nova Southeastern University)
Collado, Fanny (South Florida Veterans Affairs Foundation for Research and Education Inc)
Almenar-Pérez, Eloy (Universidad Católica de Valencia)
Martín-Martínez, Eva (Hospital de Manises (València))
Alegre Martín, José (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fletcher, Mary A. (South Florida Veterans Affairs Foundation for Research and Education Inc)
Klimas, Nancy G. (South Florida Veterans Affairs Foundation for Research and Education Inc)
Oltra, Elisa (Universidad Católica de Valencia)
Nathanson, Lubov (Nova Southeastern University)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post-exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender-based miRNAs importantly provides new insights into gender-specific ME/CFS susceptibility and demands exploration of sex-suited ME/CFS therapeutics.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Exercise ; Gender ; Immune function ; Inflammation ; MicroRNAs ; Myalgic encephalomyelitis/chronic fatigue syndrome ; Peripheral blood mononuclear cell
Published in:	Journal of Cellular and Molecular Medicine, Vol. 24 (april 2020) , p. 5865-5877, ISSN 1582-4934

DOI: 10.1111/jcmm.15260
PMID: 32291908

13 p, 1.6 MB

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