The autophagic marker p62 highlights Alzheimer type astrocytes in metabolic/hepatic encephalopathy
Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Rahimi, Jasmin (Danube Hospital)
Klotz, Sigrid (Medical University of Vienna)
Schmid, Susanne (Medical University of Vienna)
Ricken, Gerda (Medical University of Vienna)
Forcen-Vega, Sara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Budka, Herbert (Medical University of Vienna)
Kovacs, Gabor G. (University Health Network)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Metabolic/hepatic encephalopathy is neuropathologically characterized by the presence of Alzheimer type II astrocytes (AA II) with large and clear nuclear morphology. To date, there is no good immunohistochemical marker to better identify these cells. Here, we assessed cases of hepatic encephalopathy of different etiologies by immunohistochemistry using an anti-p62 antibody. We observed peripheral or diffuse nuclear staining of variable intensity in AA II in all cases but not in normal controls or reactive astrocytes. We conclude that p62 is a useful immunohistochemical marker for the identification of AA II and may be helpful for the neuropathological diagnosis of metabolic/hepatic encephalopathy in difficult or equivocal cases.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alzheimer type II astrocytes ; Astrogliopathy ; Hepatic encephalopathy ; Metabolic encephalopathy ; P62
Published in:	Neuropathology, Vol. 40 (june 2020) , p. 358-366, ISSN 1440-1789

DOI: 10.1111/neup.12660
PMID: 32483828

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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