Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients
Ji, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Lin, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health)
Shen, S. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University)
Dong, X. (Department of Epidemiology and Biostatistics. School of Public Health. Southeast University)
Chen, C. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Li, Y. (Department of Biostatistics. University of Michigan)
Zhu, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Huang, H. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Chen, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Chen, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Wei, Liangmin (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
He, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Duan, W. (Department of Bioinformatics. School of Biomedical Engineering and Informatics. Nanjing Medical University)
Su, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health)
Jiang, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Fan, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
Guan, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University)
You, D. (Department of Environmental Health. Harvard T.H. Chan School of Public Health)
Shafer, A. (Harvard Medical School)
Bjaanæs, Maria Moksnes (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital)
Karlsson, A. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University)
Planck, M. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University)
Staaf, J. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University)
Helland, Å. (Institute of Clinical Medicine. University of Oslo)
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Wei, Y. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University)
Zhang, R. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University)
Chen, F. (Jiangsu Key Lab of Cancer Biomarkers. Prevention and Treatment. Cancer Center. Collaborative Innovation Center for Cancer Personalized Medicine. Nanjing Medical University)
Christiani, David C (Harvard Medical School)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407 was significantly associated with overall survival in patients with LUSC (HR = 1. 65, 95% CI: 1. 30-2. 09, P = 4. 52 × 10), but not in patients with LUAD (HR = 1. 08, 95% CI: 0. 87-1. 33, P = 0. 493). As incidence of LUSC is associated with higher smoking intensity compared to LUAD, we investigated whether smoking intensity impacted on the prognostic effect of cg05293407 methylation in NSCLC. LUSC patients had a higher average pack-year of smoking (37. 49 vs 54. 79, P = 1. 03 × 10) and included a higher proportion of current smokers than LUAD patients (28. 24% vs 34. 09%, P = 0. 037). cg05293407 was significantly associated with overall survival only in NSCLC patients with medium-high pack-year of smoking (HR = 1. 58, 95% CI: 1. 26-1. 96, P = 5. 25 × 10). We conclude that cg05293407 methylation is a potential predictor of LUSC prognosis, and smoking intensity may impact on its prognostic value across the various types of NSCLC.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	TRIM27 ; DNA methylation ; Interaction ; Non-small-cell lung cancer ; Overall survival ; Prognosis
Published in:	Molecular Oncology, Vol. 14 Núm. 11 (january 2020) , p. 2759-2774, ISSN 1878-0261

DOI: 10.1002/1878-0261.12785
PMID: 33448640

16 p, 1.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Research articles
Articles > Published articles