Plant geranylgeranyl diphosphate synthases : every (gene) family has a story
Barja, Maria Victoria (Centre de Recerca en Agrigenòmica)
Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica)

Data:	2021
Resum:	Plant isoprenoids (also known as terpenes or terpenoids) are a wide family of primary and secondary metabolites with multiple functions. In particular, most photosynthesis-related isoprenoids (including carotenoids and chlorophylls) as well as diterpenes and polyterpenes derive from geranylgeranyl diphosphate (GGPP) produced by GGPP synthase (GGPPS) enzymes in several cell compartments. Plant genomes typically harbor multiple copies of differentially expressed genes encoding GGPPS-like proteins. While sequence comparisons allow to identify potential GGPPS candidates, experimental evidence is required to ascertain their enzymatic activity and biological function. Actually, functional analyses of the full set of potential GGPPS paralogs are only available for a handful of plant species. Here we review our current knowledge on the GGPPS families of the model plant Arabidopsis thaliana and the crop species rice (Oryza sativa), pepper (Capsicum annuum) and tomato (Solanum lycopersicum). The results indicate that a major determinant of the biological role of particular GGPPS paralogs is the expression profile of the corresponding genes even though specific interactions with other proteins (including GGPP-consuming enzymes) might also contribute to subfunctionalization. In some species, however, a single GGPPS isoforms appears to be responsible for the production of most if not all GGPP required for cell functions. Deciphering the mechanisms regulating GGPPS activity in particular cell compartments, tissues, organs and plant species will be very useful for future metabolic engineering approaches aimed to manipulate the accumulation of particular GGPP-derived products of interest without negatively impacting the levels of other isoprenoids required to sustain essential cell functions.
Ajuts:	Ministerio de Economía y Competitividad BIO2017-84041-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-710 Ministerio de Educación y Ciencia FPU14/05142
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article de revisió ; Article ; Versió acceptada per publicar
Matèria:	Geranylgeranyl diphosphate ; GGPP ; GGPP synthase ; Isoprenoid ; Isoprenyl transferase
Publicat a:	aBIOTECH, Vol. 2, Issue 3 (September 2021) , p. 289-298, ISSN 2662-1738

DOI: 10.1007/s42994-021-00050-5
PMID: 36303884

Postprint 14 p, 364.9 KB

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