Neurological manifestations and implications of COVID-19 pandemic
Tsivgoulis, Georgios (Kapodistrian University of Athens)
Palaiodimou, Lina (Kapodistrian University of Athens)
Katsanos, Aristeidis H. (Kapodistrian University of Athens)
Caso, Valeria (University of Perugia)
Köhrmann, Martin (University of Essen)
Molina, Carlos (Hospital Universitari Vall d'Hebron)
Cordonnier, Charlotte (University of Lille)
Fischer, Urs (University of Bern)
Kelly, Peter (Mater Misericordiae University Hospital(Dublín, Irlanda))
Sharma, Vijay K. (National University Hospital (Singapore))
Chan, Amanda C. (National University Hospital (Singapore))
Zand, Ramin (Geisinger Health System)
Sarraj, Amrou (The University of Texas at Houston)
Schellinger, Peter D. (University Clinic RUB)
Voumvourakis, Konstantinos I. (Kapodistrian University of Athens)
Grigoriadis, Nikolaos (Aristotelion University of Thessaloniki)
Alexandrov, Andrei V (The University of Tennessee Health Science Center)
Tsiodras, Sotirios (Kapodistrian University of Athens)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide, with a vast majority of confirmed cases presenting with respiratory symptoms. Potential neurological manifestations and their pathophysiological mechanisms have not been thoroughly established. In this narrative review, we sought to present the neurological manifestations associated with coronavirus disease 2019 (COVID-19). Case reports, case series, editorials, reviews, case-control and cohort studies were evaluated, and relevant information was abstracted. Various reports of neurological manifestations of previous coronavirus epidemics provide a roadmap regarding potential neurological complications of COVID-19, due to many shared characteristics between these viruses and SARS-CoV-2. Studies from the current pandemic are accumulating and report COVID-19 patients presenting with dizziness, headache, myalgias, hypogeusia and hyposmia, but also with more serious manifestations including polyneuropathy, myositis, cerebrovascular diseases, encephalitis and encephalopathy. However, discrimination between causal relationship and incidental comorbidity is often difficult. Severe COVID-19 shares common risk factors with cerebrovascular diseases, and it is currently unclear whether the infection per se represents an independent stroke risk factor. Regardless of any direct or indirect neurological manifestations, the COVID-19 pandemic has a huge impact on the management of neurological patients, whether infected or not. In particular, the majority of stroke services worldwide have been negatively influenced in terms of care delivery and fear to access healthcare services. The effect on healthcare quality in the field of other neurological diseases is additionally evaluated.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Cerebrovascular diseases ; COVID-19 ; Healthcare impact ; Neurological manifestations ; SARS-CoV-2
Published in:	Therapeutic Advances in Neurological Disorders, Vol. 13 (2020) , ISSN 1756-2864

DOI: 10.1177/1756286420932036
PMID: 32565914

14 p, 919.8 KB

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