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Pàgina inicial > Articles > Articles publicats > Propagation patterns of jejunal motor activity measured by high-resolution water-perfused manometry |
Data: | 2021 |
Resum: | Background: The manometric diagnosis of severe intestinal dysmotility is performed at most institutions using catheters with 2-8 sensors 5-10 cm apart. The recent application of high-resolution manometry catheters with closely spaced sensors to other gut segments has been highly successful. The objective of the present study was to determine the feasibility of a jejunal high-resolution manometry method and to carry out a descriptive analysis of normal jejunal motor function. Methods: A 36-channel high-resolution water-perfused manometry catheter (MMS-Laborie, Enschede, The Netherlands) was orally placed in the jejunum of 18 healthy subjects (10 men, eight women; 21-38 age range). Intestinal motility was recorded during 5 h, 3 during fasting, and 2 after a 450 kcal solid-liquid meal. Analysis of motility patterns was supported by computerized tools. Key Results: All healthy subjects except one showed at least one complete migrating motor complex during the 3 h fasting period. Phase III activity lasted 5 ± 1 min and migrated aborally at a velocity of 7 ± 3 cm/min. High-resolution spatial analysis showed that during phase III each individual contraction propagated rapidly (75 ± 37 cm/min) over a 32 ± 10 cm segment of the jejunum. During phase II, most contractile activity corresponded to propagated contractile events which increased in frequency from early to late phase II (0. 5 ± 0. 9 vs 2. 5 ± 1. 3 events/10 min, respectively; p < 0. 001). After meal ingestion, non-propagated activity increased, whereas propagated events were less frequent than during late phase II. Conclusions & Inferences: Jejunal motility analysis with high-resolution manometry identifies propagated contractile patterns which are not apparent with conventional manometric catheters. |
Ajuts: | Instituto de Salud Carlos III PI17/01794 Ministerio de Economía y Competitividad SAF 2016-76648-R Instituto de Salud Carlos III CM20/00182 |
Nota: | Altres ajuts: acords transformatius de la UAB |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | High-resolution intestinal manometry ; Intestinal motility ; Postprandial motility ; Propagated contractions |
Publicat a: | Neurogastroenterology and Motility, 33 (2021) , ISSN 1365-2982 |
8 p, 1.5 MB |