Obesity and Breast Cancer : a Paradoxical and Controversial Relationship Influenced by Menopausal Status
García-Estévez, Laura (Centro de Investigación Biomédica en Red de Cáncer)
Cortés, Javier (Vall d'Hebron Institut d'Oncologia)
Pérez, Silvia (Breast Cancer Department, MD Anderson Cancer Center)
Calvo Plaza, Isabel (Breast Cancer Department, MD Anderson Cancer Center)
Gallegos, Isabel (Breast Cancer Department, MD Anderson Cancer Center)
Moreno-Bueno, Gema (MD Anderson International Foundation)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Breast cancer is the most common tumor in women worldwide, and an increasing public health concern. Knowledge of both protective and negative risk factors is essential for a better understanding of this heterogenous disease. We undertook a review of the recent literature and evaluated the relationship between obesity mediators and breast cancer development depending on menopausal status. Excess weight is now pandemic and has replaced tobacco as the main lifestyle-related risk factor for premature death. Although the prevalence of obesity/overweight has increased globally over the last 50 years, the potential harm attributable to excess fat has generally been underestimated. The relationship between overweight/obesity, breast cancer and overall risk appears to be highly dependent on menopausal status. Thus, obesity increases the risk of breast cancer in postmenopausal women but, conversely, it appears to be protective in premenopausal women. We evaluate the role of different clinical factors potentially involved in this seemingly contradictory relationship, including estrogen, mammogram density, adipokines, insulin-signaling pathway activation, and inflammatory status. A key focus of this review is to better understand the impact of body mass index and menopausal status on these clinical factors and, hence, provide some clarity into the inter-relationships involved in this controversial issue.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Overweight ; Menopause ; Estrogen ; Mammogram ; Adipocytokine ; Insulin ; Obesity
Published in:	Frontiers in Oncology, Vol. 11 (august 2021) , ISSN 2234-943X

DOI: 10.3389/fonc.2021.705911
PMID: 34485137

10 p, 621.9 KB

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