Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
Borràs, Jordi (Universitat Autònoma de Barcelona. Departament de Química)
Lecina Vicente, Joan (Universitat Autònoma de Barcelona. Departament de Química)
Foster, Julie (Queen Mary University of London. John Vane Science Centre)
Kashani, Roxana (Queen Mary University of London. John Vane Science Centre)
Melendez-Alafort, L. (Istituto Oncologico Veneto IRCCS)
Sosabowski, Jane (Queen Mary University of London. John Vane Science Centre)
Suades Ortuño, Joan (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2021
Abstract:	The transmetalation reaction between zinc dithiocarbamates functionalized with organic groups and the cation fac-[Tc(HO)(CO)] has been studied as a new strategy to bind biomolecules to this radionuclide for preparing radiopharmaceuticals with high molar activity. All complexes were obtained in high yields by heating at moderate temperatures and without subsequent purification. The chemical identity was ascertained by HPLC comparison with the homologous rhenium complexes. Stability studies in cysteine solution and serum have shown a good stability of the coordination set fac-[Tc(CO)(SS)(P)]. Preliminary biological studies of the radiocomplex functionalized with D-(+)-glucosamine with carcinoma cells have been performed.
Grants:	Ministerio de Economía y Competitividad BIO2015-67358-C2-2-P Ministerio de Economía y Competitividad CTQ2015-70371-REDT Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-795
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Technetium ; Carbonyl ; Radiopharmaceutical ; Transmetallation ; Rhenium
Published in:	Bioorganic and Medicinal Chemistry Letters, Vol. 37 (April 2021) , art. 127840, ISSN 1464-3405

DOI: 10.1016/j.bmcl.2021.127840
PMID: 33556570

6 p, 2.3 MB

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