Peritoneal bile acids concentration in adult horses with hepatic and gastrointestinal disorders
Rodríguez-Pozo, M. L. (Hospital Veterinario San Vicente (Alacant))
Armengou Ruiz, Lara (Universitat Autònoma de Barcelona. Fundació Hospital Clínic Veterinari)
Viu Mella, Judit (Universitat Autònoma de Barcelona. Fundació Hospital Clínic Veterinari)
Ríos, José (Hospital Veterinario Sierra de Madrid)
José Cunilleras, Eduard (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Data:	2021
Resum:	Background: Peritoneal bile acids concentration (PBAC) has not been previously reported in horses. A case of liver lobe torsion in which increased PBAC was detected prompted us to study PBAC in horses. Objectives: (a) To determine a reference range of PBAC in horses; (b) to compare PBAC from horses with either hepatic or gastrointestinal disease and healthy horses and (c) to assess the prognostic and diagnostic values of PBAC. Study design: Prospective case-control. Methods: Prospective observational clinical study. Bile acids concentrations were measured in both plasma and peritoneal fluid in selected clinical patients with hepatic or gastrointestinal disease (n = 108) and healthy horses (n = 11). Sixty-eight of 108 patients survived to hospital discharge, and the remaining 40 were nonsurvivors. Additionally, other haematological and biochemistry analyses were performed. Results: Sick horses were classified according to diagnosis into hepatic (n = 13), gastrointestinal (GI) obstructive (n = 48) and GI ischaemic-inflammatory (n = 47) groups. The hepatic group had significantly higher PBAC (6. 8 [2. 3-9. 4]; median [IQR]) than the control (1. 0 [0. 6-1. 5]) and GI obstructive groups (1. 2 [0. 8-1. 7] µmol/L; P <. 001). Moreover, the GI ischaemic-inflammatory group (3. 3 [1. 4-5. 5]) also had significantly higher values than the control and GI obstructive groups (P <. 001). Regarding outcome, the nonsurvivor group (n = 40) had significantly higher median PBAC value than the survivor group (n = 68, 4. 1 [1. 6-6. 5] vs 1. 3 [0. 8-3]; P <. 001). Main limitations: A higher number of horses with abdominal disease is required to confirm the clinical significance of these findings. Conclusions: PBAC may have a role in the diagnosis of hepatic and gastrointestinal disease and as a prognostic tool in horses with abdominal pain.
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Equine Veterinary Journal, 2021 , ISSN 2042-3306

DOI: 10.1111/evj.13538
PMID: 34743363

8 p, 609.0 KB

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