Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection
Belarte Tornero, Laia Carla (Institut Hospital del Mar d'Investigacions Mèdiques)
Valdivielso Moré, Sandra (Hospital del Mar (Barcelona, Catalunya))
Vicente Elcano, Miren (Hospital del Mar (Barcelona, Catalunya))
Solé González, Eduard (Hospital del Mar (Barcelona, Catalunya))
Ruiz Bustillo, Sonia (Hospital del Mar (Barcelona, Catalunya))
Calvo-Fernández, Alicia (Hospital del Mar (Barcelona, Catalunya))
Subinara, Isaac (Institut Hospital del Mar d'Investigacions Mèdiques)
Cabero, Paula (Hospital del Mar (Barcelona, Catalunya))
Soler, Cristina (Hospital del Mar (Barcelona, Catalunya))
Cubero-Gallego, Hector (Hospital del Mar (Barcelona, Catalunya))
Vaquerizo, Beatriz (Universitat Autònoma de Barcelona. Departament de Medicina)
Farré, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2021
Abstract:	Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51. 2% vs. 29. 1%, p = 0. 014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2. 3, confidence interval (CI) 95%: 1. 26-2. 4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51. 2%. CHF was independently associated with all-cause mortality (HR 2. 3, CI 95% 1. 26-4. 2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; SARS-CoV-2 ; Coronavirus ; Heart failure ; Prognosis ; Biomarkers ; NT-proBNP ; Troponin
Published in:	Journal of clinical medicine, Vol. 10 (january 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10020323
PMID: 33477268

14 p, 1.5 MB

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