Stroke etiologies in patients with COVID-19 : the SVIN COVID-19 multinational registry
Ramos-Araque, María E. (Hospital Clínico Universitario de Valladolid)
Siegler, James E. (Cooper University Hospital. Cooper Neurologic Institute)
Ribo, Marc (Hospital Universitari Vall d'Hebron)
Requena, Manuel (Hospital Universitari Vall d'Hebron)
López, Cristina (Hospital Clínico Universitario de Valladolid)
De Lera Alfonso, Mercedes (Hospital Clínico Universitario de Valladolid)
Arenillas, Juan F.. (Hospital Clínico Universitario de Valladolid)
Hernández Pérez, Isabel (Hospital Clínico Universitario de Valladolid)
Gómez-Vicente, Beatriz (Hospital Clínico Universitario de Valladolid)
Talavera, Blanca (Hospital Clínico Universitario de Valladolid)
Portela, Pere Cardona (Hospital Universitari de Bellvitge)
Guillen, Ana Nuñez (Hospital Universitari de Bellvitge)
Urra, Xabier (Hospital Clínic i Provincial de Barcelona)
Llull, Laura (Hospital Clínic i Provincial de Barcelona)
Renú, Arturo (Hospital Clínic i Provincial de Barcelona)
Nguyen, Thanh N. (Boston University School of Medicin)
Jillella, Dinesh (Emory University School of Medicine)
Nahab, Fadi (Emory University School of Medicine)
Nogueira, Raul (Grady Memorial Hospital)
Haussen, Diogo (Grady Memorial Hospital)
Then, Ryna (Cooper University Hospital)
Thon, Jesse M. (Cooper University Hospital)
Esparragoza, Luis Rodríguez (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bustamante, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mansour, Ossama Yassin
Megahed, Mohammed (Alexandria University)
Hassan, Tamer (Alexandria University)
Liebeskind, David S. (Ronald Reagan UCLA Medical Center)
Hassan, Ameer E (University of Texas Rio Grande Valley)
Bushnaq, Saif (Bon Secours Mercy Health St. Vincent Hospital, Toledo, OH USA)
Osman, Mohamed (Bon Secours Mercy Health St. Vincent Hospital, Toledo, OH USA)
Vazquez, Alejandro Rodriguez (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20). Of the 14. 483 laboratory-confirmed patients with COVID-19, 156 (1. 1%) were diagnosed with AIS. Sixty-one (39. 4%) were female, 84 (67. 2%) white, and 88 (61. 5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42. 6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p</=0. 05 for all comparisons). In a multivariable backward stepwise regression model estimating the odds of in-hospital mortality, cryptogenic stroke mechanism was associated with a fivefold greater odds in-hospital mortality than strokes due to any other mechanism (adjusted OR 5. 16, 95%CI 1. 41-18. 87, p = 0. 01). In that model, older age (aOR 2. 05 per decade, 95%CI 1. 35-3. 11, p < 0. 01) and higher baseline NIHSS (aOR 1. 12, 95%CI 1. 02-1. 21, p = 0. 01) were also independently predictive of mortality. Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality. The online version contains supplementary material available at 10. 1186/s12883-021-02075-1.
Ayudas:	Instituto de Salud Carlos III JR19/00020
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Stroke ; COVID-19 ; Coronavirus ; Cryptogenic ; Mortality
Publicado en:	BMC Neurology, Vol. 21 (january 2021) , ISSN 1471-2377

DOI: 10.1186/s12883-021-02075-1
PMID: 33514335

11 p, 623.7 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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