Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease
Dávalos-Yerovi, Vanesa (Institut Hospital del Mar d'Investigacions Mèdiques)
Marco, Ester (Universitat Autònoma de Barcelona)
Sánchez-Rodríguez, Dolores (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Meza-Valderrama, Delky (Caja de Seguro Social (Panamà))
Rodríguez, Diego Agustín (Universitat Autònoma de Barcelona)
Muñoz Gómez, Elena (Institut Hospital del Mar d'Investigacions Mèdiques)
Tejero-Sánchez, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Muns, Maria Dolors (Hospital del Mar (Barcelona, Catalunya))
Guillén-Solà, Anna (Universitat Autònoma de Barcelona)
Duarte Oller, Esther (Universitat Autònoma de Barcelona)

Date:	2021
Abstract:	Malnutrition has a negative impact on patients with chronic pulmonary obstructive disease (COPD). The purpose of this study was to assess the prevalence of malnutrition, defined by the Global Leadership Initiative for Malnutrition (GLIM), in stable COPD patients referred to pulmonary rehabilitation, and to explore potential associations of malnutrition according to GLIM, and its components, with increased risk of mortality and hospitalizations in 2 years. In a post-hoc analysis of a prospective cohort of 200 rehabilitation patients with stable COPD, main outcome variables were hospital admissions, length of stay, and mortality during a 2-year follow-up. Covariates were malnutrition according to GLIM and its phenotypic criteria: unintentional weight loss, low body mass index (BMI), and low fat-free mass (FFM). Univariate and multivariate analysis were performed using logistic and proportional hazard Cox regression. Malnutrition according to GLIM showed 45% prevalence and was associated with increased mortality risk. Low age-related BMI and FFM were independently associated with mortality, which persisted after adjustment for age and lung function. Malnutrition and low BMI were also associated with increased risk of hospitalization. Malnutrition according to GLIM criteria was highly prevalent in rehabilitation patients with COPD and was associated with nearly 3 times greater mortality and hospitalization risk.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Malnutrition ; GLIM ; Mortality ; Hospitalization ; Chronic pulmonary obstructive disease ; Rehabilitation
Published in:	Nutrients, Vol. 13 (january 2021) , ISSN 2072-6643

DOI: 10.3390/nu13020369
PMID: 33530364

11 p, 298.5 KB

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