Matrix Metalloproteinases in Diabetic Kidney Disease
García-Fernández, Nuria (Instituto de Investigación Sanitaria de Navarra)
Jacobs-Cachá, Conxita (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Mora-Gutiérrez, José María (Universidad de Navarra)
Vergara, Ander (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Orbe, Josune (Universidad de Navarra)
Soler, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Around the world diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy, and interstitial fibrosis. The hallmark of the pathogenesis of DKD is an increased extracellular matrix (ECM) accumulation causing thickening of the glomerular and tubular basement membranes, mesangial expansion, sclerosis, and tubulointerstitial fibrosis. The matrix metalloproteases (MMPs) family are composed of zinc-dependent enzymes involved in the degradation and hydrolysis of ECM components. Several MMPs are expressed in the kidney; nephron compartments, vasculature and connective tissue. Given their important role in DKD, several studies have been performed in patients with DKD proposing that the measurement of their activity in serum or in urine may become in the future markers of early DKD. Studies from diabetic nephropathy experimental models suggest that a balance between MMPs levels and their inhibitors is needed to maintain renal homeostasis. This review focuses in the importance of the MMPs within the kidney and their modifications at the circulation, kidney and urine in patients with DKD. We also cover the most important studies performed in experimental models of diabetes in terms of MMPs levels, renal expression and its down-regulation effect.
Grants:	Ministerio de Economía y Competitividad RD16/0009/0030
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Matrix metalloproteinases ; Diabetic kidney disease ; Experimental models of diabetes ; Tissue inhibitors of metalloproteinases
Published in:	Journal of clinical medicine, Vol. 9 (february 2020) , ISSN 2077-0383

DOI: 10.3390/jcm9020472
PMID: 32046355

17 p, 896.1 KB

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