Histone H1 Post-Translational Modifications : Update and Future Perspectives
Andrés Nieto, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Garcia-Gomis, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Ponte Marull, Immaculada (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Suau, Pedro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Roque Córdova, Alicia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date:	2020
Abstract:	Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes. The H1 subtype composition is different among cell types during the cell cycle and differentiation. Mass spectrometry-based proteomics has added a new layer of complexity with the identification of a large number of post-translational modifications (PTMs) in H1. In this review, we summarize histone H1 PTMs from lower eukaryotes to humans, with a particular focus on mammalian PTMs. Special emphasis is made on PTMs, whose molecular function has been described. Post-translational modifications in H1 have been associated with the regulation of chromatin structure during the cell cycle as well as transcriptional activation, DNA damage response, and cellular differentiation. Additionally, PTMs in histone H1 that have been linked to diseases such as cancer, autoimmune disorders, and viral infection are examined. Future perspectives and challenges in the profiling of histone H1 PTMs are also discussed.
Grants:	Agencia Estatal de Investigación BFU2017-82805-C2-2-P
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Histone H1 ; Chromatin structure ; PTM function ; Disease ; Phosphorylation ; Methylation ; Acetylation ; Ubiquitylation ; Citrullination ; Mass spectrometry
Published in:	International journal of molecular sciences, Vol. 21, Num. 16 (August 2020) , art. 5941, ISSN 1422-0067

DOI: 10.3390/ijms21165941
PMID: 32824860

23 p, 4.4 MB

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