Prolonged QT Interval in SARS-CoV-2 Infection : Prevalence and Prognosis
Farré, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Mojón, Diana (Hospital del Mar (Barcelona, Catalunya))
Llagostera-Martín, Marc (Hospital del Mar (Barcelona, Catalunya))
Belarte Tornero, Laia Carla (Institut Hospital del Mar d'Investigacions Mèdiques)
Calvo-Fernández, Alicia (Universitat Autònoma de Barcelona. Departament de Medicina)
Vallés, Ermengol (Institut Hospital del Mar d'Investigacions Mèdiques)
Negrete, Alejandro (Hospital del Mar (Barcelona, Catalunya))
García-Guimaraes, Marcos (Hospital del Mar (Barcelona, Catalunya))
Bartolomé, Yolanda (Hospital del Mar (Barcelona, Catalunya))
Fernández, Camino (Hospital del Mar (Barcelona, Catalunya))
García-Duran, Ana B. (Hospital del Mar (Barcelona, Catalunya))
Marrugat, Jaume 1954- (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Vaquerizo, Beatriz (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2020
Resum:	Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection is not well known. Objective: To determine whether the presence of a prolonged QT on admission is an independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-center cohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2, recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval >480 milliseconds. Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9. 8%) had prolonged QTc and only 3. 2% had a baseline QTc > 500 milliseconds. Patients with prolonged QTc were older, had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodes of ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death was higher in patients with prolonged QTc (41. 0% vs. 8. 7%, p < 0. 001, multivariable HR 2. 68 (1. 58-4. 55), p < 0. 001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTc interval on admission. A prolonged QTc was independently associated with a higher mortality even after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin. An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	QT interval ; COVID-19 ; Hydroxychloroquine ; Azithromycin ; Prognosis ; Death
Publicat a:	Journal of clinical medicine, Vol. 9 (august 2020) , ISSN 2077-0383

DOI: 10.3390/jcm9092712
PMID: 32839385

15 p, 761.3 KB

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