Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application
Alvarez-Palomo, Belén (Banc de Sang i Teixits)
Vives Armengol, Joaquim (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Casaroli-Marano, Ricardo Pedro (Institut d'Investigació Biomèdica Sant Pau)
G. Gómez, Susana (Banc de Sang i Teixits)
Rodriguez Gómez, Luciano (Banc de Sang i Teixits)
Edel, Michael J.. (Centre d'Oftalmologia Barraquer (Barcelona, Catalunya))
Querol, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	In this article, we will discuss the main aspects to be considered to define standard operation procedures (SOPs) for the creation of an induced pluripotent stem cell (iPSC) bank using cord blood (CB)-or similar cell type-bank guidelines for clinical aims. To do this, we adapt the pre-existing SOP for CB banking that can be complementary for iPSCs. Some aspects of iPSC manufacturing and the particular nature of these cells call for special attention, such as the potential multiple applications of the cells, proper explanation to the donor for consent of use, the genomic stability and the risk of genetic privacy disclosure. Some aspects of the iPSC SOP are solidly established by CB banking procedures, other procedures have good consensus in the scientific and medical community, while others still need to be further debated and settled. Given the international sharing vocation of iPSC banking, there is an urgent need by scientists, clinicians and regulators internationally to harmonize standards and allow future sample interchange between many iPSC bank initiatives that are springing up worldwide.
Grants:	Ministerio de Ciencia e Innovación RTC-2017-6000-1 Ministerio de Ciencia e Innovación RD16/0011/0028
Note:	Altres ajuts: TV3 Maraton 2018-FBG project 309768(M.J.E).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	SOP ; Cord blood bank ; Induced pluripotent stem cells ; Cell therapy ; Advanced therapies medicinal products ; HLA haplobank
Published in:	Journal of clinical medicine, Vol. 8 (april 2019) , ISSN 2077-0383

DOI: 10.3390/jcm8040476
PMID: 30965661

15 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles