Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter
Kuypers, Kim P. C. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
De La Torre, Rafael (Universitat Pompeu Fabra)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Xicota, Laura (Institut Hospital del Mar d'Investigacions Mèdiques)
de Sousa Fernandes Perna, Elizabeth B. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
Theunissen, E. L. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
Ramaekers, Johannes G. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia

Date:	2018
Abstract:	MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic variant ('s-group') of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are homozygous for the l-allele ('l-group'). The present study aimed to investigate the role of the 5-HTTLPR polymorphism in MDMA-induced mood effects. Four placebo-controlled, within-subject studies were pooled, including in total 63 polydrug ecstasy users (N = 48; N = 15) receiving MDMA 75 mg and placebo on two test days, separated by minimally 7 days. Mood was assessed by means of the Profile of Mood States. Findings showed that MDMA induced -independent of sex- a positive mood state, and as a side effect also increased two negative affect states, anxiety and confusion. Anxiety ratings were higher in the l-group and independent of treatment or sex. Depression ratings were lowered by MDMA in the female l-group. Findings indicate that the MDMA-induced reduction in self-rated depressive feelings is sex- and genotype-dependent, with females homozygous for the l-allele showing this beneficial effect.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR 680
Note:	Altres ajuts: Dutch Organisation for Scientifc Research, 400-07-213, 400-05-096, 400-07-2013
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Scientific reports, Vol. 8 (january 2018) , ISSN 2045-2322

DOI: 10.1038/s41598-018-19618-1
PMID: 29348651

7 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles