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| Pàgina inicial > Articles > Articles publicats > Validating a breast cancer score in Spanish women. The MCC-Spain study |
(Universidad de Cantabria) (Universidad de Cantabria) (IIS Puerta de Hierro) (Universitat Pompeu Fabra) (Universidad de Cantabria) (Universidad de Oviedo) (Agencia Valenciana de Salud) (Institut Català d'Oncologia) (Universitat de Barcelona. Departament de Ciències Clíniques) (IIS Puerta de Hierro) (School of Public Health (Grècia)) (IIS Puerta de Hierro) (Universidad de Cantabria)| Data: | 2018 |
| Resum: | A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0. 6195, 0. 5885 and 0. 5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23. 6% (NRI = 0. 236), while the modifiable factor score only improved it by 7. 2%. The full model AUROC reached 0. 6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations. |
| Ajuts: | Instituto de Salud Carlos III PI08/1770 Instituto de Salud Carlos III PI08/0533 Instituto de Salud Carlos III PI08/1359 Instituto de Salud Carlos III PI09/00773 Instituto de Salud Carlos III PI09/01286 Instituto de Salud Carlos III PI09/01903 Instituto de Salud Carlos III PI09/02078 Instituto de Salud Carlos III PI09/01662 Instituto de Salud Carlos III PI11/01403 Instituto de Salud Carlos III PI11/01889 Instituto de Salud Carlos III PI11/00226 Instituto de Salud Carlos III PI11/01810 Instituto de Salud Carlos III PI11/02213 Instituto de Salud Carlos III PI12/00488 Instituto de Salud Carlos III PI12/00265 Instituto de Salud Carlos III PI12/01270 Instituto de Salud Carlos III PI12/00715 Instituto de Salud Carlos III PI12/00150 Instituto de Salud Carlos III PI14/01219 Ministerio de Economía, Industria y Competitividad RD12/0036/0036 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009SGR1489 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Publicat a: | Scientific reports, Vol. 8 (february 2018) , ISSN 2045-2322 |
