Immune Modulation by Human Secreted RNases at the Extracellular Space
Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Li, Jiarui (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Moussaoui, Mohammed (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Data:	2018
Resum:	The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses eight functional members in humans. The proteins are secreted by diverse innate immune cells, from blood cells to epithelial cells and their levels in our body fluids correlate with infection and inflammation processes. Recent studies ascribe a prominent role to secretory RNases in the extracellular space. Extracellular RNases endowed with immuno-modulatory and antimicrobial properties can participate in a wide variety of host defense tasks, from performing cellular housekeeping to maintaining body fluid sterility. Their expression and secretion are induced in response to a variety of injury stimuli. The secreted proteins can target damaged cells and facilitate their removal from the focus of infection or inflammation. Following tissue damage, RNases can participate in clearing RNA from cellular debris or work as signaling molecules to regulate the host response and contribute to tissue remodeling and repair. We provide here an overall perspective on the current knowledge of human RNases' biological properties and their role in health and disease. The review also includes a brief description of other vertebrate family members and unrelated extracellular RNases that share common mechanisms of action. A better knowledge of RNase mechanism of actions and an understanding of their physiological roles should facilitate the development of novel therapeutics.
Ajuts:	Ministerio de Economía y Competitividad SAF2015-66007P Agència de Gestió d'Ajuts Universitaris i de Recerca 2016/PROD-00060 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1010
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Ribonucleases ; Innate immunity ; RNA ; Extracellular ; Inflammation ; Infection
Publicat a:	Frontiers in immunology, Vol. 9 (May 2018) , art. 1012, ISSN 1664-3224

DOI: 10.3389/fimmu.2018.01012
PMID: 29867984

20 p, 831.5 KB

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