| Abstract: |
Supplemental Digital Content is available in the text In cancer patients, who are frequently immunocompromised, bacterial meningitis (BM) can be a severe complication, with a different presentation, etiology, and course, compared to patients without cancer. Our objective is to compare the characteristics and outcomes of BM in patients with and without cancer. A single-center, prospective observational cohort study, conducted between 1982 and 2012, in a tertiary university hospital in Barcelona (Spain). The main outcome measure is in-hospital mortality. We evaluated 659 episodes of BM; 97 (15%) had active cancer. Patients with malignancies were older (median 63 (interquartile range [IQR] 24) vs 52 [IQR 42] years, P < . 001) and more often had a Charlson comorbidity score of ≥3 (51% vs 11%, P < . 001). The classic meningitis triad (35% vs 50%, P = . 05), fever (91% vs 96%, P = . 03), neck stiffness (58% vs 78%, P < . 001), headache (63% vs 77%) P = . 003), and rash (7% vs 30%, P < . 001) were less frequent. There was a longer interval between admission and antibiotic therapy (median 5 [IQR 14] vs 3 [IQR 6] hours, P < . 001). Listeria meningitis was the commonest cause of BM (29%) and was more frequent in cancer than noncancer (8%, P < . 001) patients, whereas meningococcal meningitis was much less frequent (4% vs 36%, P < . 001). Overall mortality was higher in patients with cancer (31% vs 16%, P < . 001), although cancer was not associated with an unfavorable outcome in the multivariate analysis (odds ratio 1. 825, P = . 07). Patients with meningitis and cancer are older and have more subtle clinical manifestations than patients without cancer. Listeria monocytogenes is the predominant pathogen and mortality is higher in cancer patients. |
guest ::
(Institut d'Investigació Biomèdica Sant Pau)
