Effects of an Exercise Programme on Functional Capacity, Body Composition and Risk of Falls in Patients with Cirrhosis : A Randomized Clinical Trial
Roman, Eva (Institut d'Investigació Biomèdica Sant Pau)
García-Galcerán, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Torrades, Teresa (Institut d'Investigació Biomèdica Sant Pau)
Herrera, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Marín, Ana (Institut d'Investigació Biomèdica Sant Pau)
Doñate, Maite (Institut d'Investigació Biomèdica Sant Pau)
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau)
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau)
Nácher, Laura (Institut d'Investigació Biomèdica Sant Pau)
Serra-Grima, Ricard (Institut d'Investigació Biomèdica Sant Pau)
Guarner, Carlos (Institut d'Investigació Biomèdica Sant Pau)
Córdoba Cardona, Juan (Hospital Universitari Vall d'Hebron)
Soriano, German (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Patients with cirrhosis often have functional limitations, decreased muscle mass, and a high risk of falls. These variables could improve with exercise. The aim was to study the effects of moderate exercise on functional capacity, body composition and risk of falls in patients with cirrhosis. Twenty-three cirrhotic patients were randomized to an exercise programme (n = 14) or to a relaxation programme (n = 9). Both programmes consisted of a one-hour session 3 days a week for 12 weeks. At the beginning and end of the study, we measured functional capacity using the cardiopulmonary exercise test, evaluated body composition using anthropometry and dual energy X-ray absorptiometry, and estimated risk of falls using the Timed Up&Go test. In the exercise group, cardiopulmonary exercise test showed an increase in total effort time (p<0. 001) and ventilatory anaerobic threshold time (p = 0. 009). Upper thigh circumference increased and mid-arm and mid-thigh skinfold thickness decreased. Dual energy X-ray absorptiometry showed a decrease in fat body mass (-0. 94 kg, 95%CI -0. 48 to -1. 41, p = 0. 003) and an increase in lean body mass (1. 05 kg, 95%CI 0. 27 to 1. 82, p = 0. 01), lean appendicular mass (0. 38 kg, 95%CI 0. 06 to 0. 69, p = 0. 03) and lean leg mass (0. 34 kg, 95%CI 0. 10 to 0. 57, p = 0. 02). The Timed Up&Go test decreased at the end of the study compared to baseline (p = 0. 02). No changes were observed in the relaxation group. We conclude that a moderate exercise programme in patients with cirrhosis improves functional capacity, increases muscle mass, and decreases body fat and the Timed Up&Go time. Trial Registration : ClinicalTrials. gov.
Note:	Altres ajuts: This study was partially funded by Fundación MAPFRE [] and Decathlon Foundation [] to buy the material and apparatus to perform the exercise and the relaxation programmes. The authors do not have any potential competing interest with the funders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 11 (march 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0151652
PMID: 27011355

15 p, 450.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles