Global Assessment of the Impact of Type 2 Diabetes on Sleep through Specific Questionnaires. A Case-Control Study
Lecube, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sánchez, Enric (Institut de Recerca Biomèdica de Lleida)
Gómez-Peralta, Fernando (Hospital Universitario Miguel Servet (Saragossa))
Abreu, Cristina (Hospital Universitario Miguel Servet (Saragossa))
Valls, Joan (Institut de Recerca Biomèdica de Lleida)
Mestre, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Romero, Odile (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martínez, María Dolores (Institut de Recerca Biomèdica de Lleida)
Sampol, Gabriel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2016
Resum:	Type 2 diabetes (T2D) is an independent risk factor for sleep breathing disorders. However, it is unknown whether T2D affects daily somnolence and quality of sleep independently of the impairment of polysomnographic parameters. A case-control study including 413 patients with T2D and 413 non-diabetic subjects, matched by age, gender, BMI, and waist and neck circumferences. A polysomnography was performed and daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS). In addition, 135 subjects with T2D and 45 controls matched by the same previous parameters were also evaluated through the Pittsburgh Sleep Quality Index (PSQI) to calculate sleep quality. Daytime sleepiness was higher in T2D than in control subjects (p = 0. 003), with 23. 9% of subjects presenting an excessive daytime sleepiness (ESS>10). Patients with fasting plasma glucose (FPG ≥13. 1 mmol/l) were identified as the group with a higher risk associated with an ESS>10 (OR 3. 9, 95% CI 1. 8-7. 9, p = 0. 0003). A stepwise regression analyses showed that the presence of T2D, baseline glucose levels and gender but not polysomnographic parameters (i. e apnea-hyoapnea index or sleeping time spent with oxigen saturation lower than 90%) independently predicted the ESS score. In addition, subjects with T2D showed higher sleep disturbances [PSQI: 7. 0 (1. 0-18. 0) vs. 4 (0. 0-12. 0), p<0. 001]. The presence of T2D and high levels of FPG are independent risk factors for daytime sleepiness and adversely affect sleep quality. Prospective studies addressed to demonstrate whether glycemia optimization could improve the sleep quality in T2D patients seem warranted.
Ajuts:	Instituto de Salud Carlos III FI12/00803
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 11 (june 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0157579
PMID: 27315083

9 p, 213.3 KB

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