Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ Concentrations in Down Syndrome Young Adults
Hoyo Soriano, Laura del (Institut Hospital del Mar d'Investigacions Mèdiques)
Xicota, Laura (Institut Hospital del Mar d'Investigacions Mèdiques)
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques)
Cuenca-Royo, Aida (Institut Hospital del Mar d'Investigacions Mèdiques)
de Sola, Susana (Institut Hospital del Mar d'Investigacions Mèdiques)
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques)
Fagundo Morales, Ana Beatriz (Hospital Universitari de Bellvitge)
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras)
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2015
Resum:	Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer's disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of Aβ peptides (Aβ and Aβ), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma Aβ concentrations, a higher DMR score and impaired communication skills (ABAS-II). The total word production and switching ability in SVFT were good indicators of plasma Aβ concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS.
Ajuts:	Ministerio de Ciencia e Innovación PI11/00744 Ministerio de Ciencia e Innovación SAF2010-19434 Ministerio de Economía y Competitividad SAF2013-49129-C2-1-R
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Down syndrome ; Alzheimer's disease ; Semantic verbal fluency ; Switching ; Aβ ; Amyloid precursor protein ; Communication skills ; DMR
Publicat a:	Frontiers in Behavioral Neuroscience, Vol. 9 (november 2015) , ISSN 1662-5153

DOI: 10.3389/fnbeh.2015.00301
PMID: 26635555

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