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Pàgina inicial > Articles > Articles publicats > Effects of Switching from Stavudine to Raltegravir on Subcutaneous Adipose Tissue in HIV-Infected Patients with HIV/HAART-Associated Lipodystrophy Syndrome (HALS). A Clinical and Molecular Study |
Data: | 2014 |
Resum: | HIV-1/HAART-associated lipodystrophy syndrome (HALS) has been associated with exposure to stavudine (d4T) through mitochondrial dysfunction. We performed a 48-week study to assess the effects of switching from d4T to raltegravir (RAL) on metabolic and fat molecular parameters of patients with HALS. Forty-two patients with HALS and a median exposure to d4T > 7 years were switched to RAL and followed for 48 weeks. Fasting metabolic tests, HIV RNA, CD4 cell count, and fat measured by DEXA were obtained at baseline and week 48. mtDNA and gene transcripts for PPAR gamma, adiponectin, cytochrome b, Cox IV, TNF alpha, MCP-1 and CD68 were assessed in paired subcutaneous fat tissue biopsies. Lipid parameters, fasting glucose, insulin, and HOMA-IR did not change significantly. Whole body fat (P = 0. 0027) and limb fat mass (P<0. 0001) increased from baseline. Trunk/limb fat ratio (P = 0. 0022), fat mass ratio (P = 0. 0020), fat mass index (P = 0. 0011) and percent leg fat normalized to BMI (P<0. 0001) improved after 48 weeks. Relative abundance of mtDNA, expression of PPAR gamma, adiponectin, Cyt b, and MCP-1 genes increased, whereas Cox IV, TNF alpha, and CD68 did not change significantly from baseline. Switching from d4T to RAL in patients with HALS is associated with an increase in limb fat mass and an improvement in markers of adipocyte differentiation and mitochondrial function in SAT. |
Ajuts: | Instituto de Salud Carlos III FIS 08/00256 Instituto de Salud Carlos III PI11/1512 Instituto de Salud Carlos III FIPSE 36610 Instituto de Salud Carlos III FIPSE 36572/06 Instituto de Salud Carlos III FIPSE 36697/07 Instituto de Salud Carlos III RIS RD12/0017/0014 Instituto de Salud Carlos III RD06/0006/0005 Instituto de Salud Carlos III INT12/383 Instituto de Salud Carlos III INT13/232 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Publicat a: | PloS one, Vol. 9 (february 2014) , ISSN 1932-6203 |
8 p, 292.0 KB |