Low HDL and high triglycerides predict COVID-19 severity
Masana, Luis (Universitat Rovira i Virgili)
Correig Fraga, Eudald (Universitat Rovira i Virgili)
Ibarretxe, Daiana (Universitat Rovira i Virgili)
Anoro, Eva (Pius Hospital de Valls)
Arroyo, Juan Antonio (Institut d'Investigació Biomèdica Sant Pau)
Jericó, Carlos (Hospital de Sant Joan Despí Moisès Broggi)
Guerrero, Carolina (Consorci Sanitari de Terrassa)
Miret, Marcel·la (Hospital de Tortosa Verge de la Cinta)
Näf, Silvia (Universitat Rovira i Virgili)
Pardo, Anna (Hospital HM Nou Delfos)
Perea, Verónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Pérez-Bernalte, Rosa (Hospital del Vendrell)
Plana, Núria (Universitat Rovira i Virgili)
Ramírez-Montesinos, Rafael (Hospital Sant Pau i Santa Tecla (Tarragona))
Royuela Juncadella, Meritxell (Fundació Althaia)
Soler, Cristina (Hospital de Santa Caterina (Salt, Girona))
Urquizu-Padilla, Maria (Hospital Universitari Vall d'Hebron)
Zamora, Alberto (Hospital Comarcal de Blanes)
Pedro-Botet, Juan (Hospital del Mar (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
Note:	Altres ajuts: The work was supported by unrestricted grants from the Institut de Investigació Sanitària Pere Virgili (IISPV) and Xarxa de Unitat de Lipids i Ateriosclerosis (XULA) de Catalunya.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Dyslipidaemias ; Risk factors
Published in:	Scientific reports, Vol. 11 (march 2021) , ISSN 2045-2322

DOI: 10.1038/s41598-021-86747-5
PMID: 33785815

9 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles