The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome : analysis of high-throughput epigenetic and gene expression studies
Malato, João (Universidade de Lisboa)
Sotzny, Franziska (Humboldt-Universität zu Berlin)
Bauer, Sandra (Charité - Universitätsmedizin Berlin)
Freitag, Helma (Charité - Universitätsmedizin Berlin)
Fonseca, André (Universidade do Algarve)
Grabowska, Anna D. (Medical University of Warsaw)
Graça, Luís (Universidade de Lisboa)
Cordeiro, Clara (Universidade do Algarve)
Nacul, Luís (British Columbia Women's Hospital and Health Centre (Canada))
Lacerda, Eliana (London School of Hygiene & Tropical Medicine)
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Scheibenbogen, Carmen (Charité - Universitätsmedizin Berlin)
Westermeier, Francisco (Universidad Bernardo O'Higgins (Xile))
Sepúlveda, Nuno (London School of Hygiene & Tropical Medicine)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Patients affected by Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) show specific epigenetic and gene expression signatures of the disease. However, it is unknown whether these signatures include abnormal levels of the human angiotensin-converting enzymes, ACE and ACE2, the latter being the main receptor described for the host-cell invasion by SARS-CoV-2. To investigate that, we first re-analyzed available case-control epigenome-wide association studies based on DNA methylation data, and case-control gene expression studies based on microarray data. From these published studies, we found an association between ME/CFS and 4 potentially hypomethylated probes located in the ACE locus. We also found another disease association with one hypomethylated probe located in the transcription start site of ACE2. The same disease associations were obtained for women but not for men after performing sex-specific analyses. In contrast, a meta-analysis of gene expression levels could not provide evidence for a differentially expression of ACE and ACE2 in affected patients when compared to healthy controls. In line with this negative finding, the analysis of a new data set on the gene expression of ACE and ACE2 in peripheral blood mononuclear cells did not find any differences between a female cohort of 37 patients and 34 age-matched healthy controls. Future studies should be conducted to extend this investigation to other potential receptors used by SARS-CoV-2. These studies will help researchers and clinicians to improve the understanding of the health risk imposed by this virus when infecting patients affected by this debilitating disease.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Human angiotensin converting enzymes 1/2 ; Epigenome-wide association studies ; Gene expression studies ; Myalgic encephalomyelitis/chronic fatigue syndrome ; SARS-CoV-2
Publicat a:	medRxiv, april 2021

DOI: 10.1101/2021.03.23.21254175
PMID: 33791744

38 p, 310.7 KB

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