Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
Morales-Quinteros, Luis (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Neto, Ary Serpa (Austin Hospital and University of Melbourne)
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Blanch, Lluís (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Botta, Michela (Amsterdam UMC Location AMC)
Kaufman, David A. (NYU School of Medicine)
Schultz, Marcus J. (Mahidol University)
Tsonas, Anissa M. (Amsterdam UMC Location AMC)
Paulus, Frederique (Amsterdam UMC Location AMC)
Bos, Lieuwe D.. (Amsterdam UMC Location AMC)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is a national, multicenter, retrospective observational study done at 22 intensive care units in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The aim was to quantify the dynamics and determine the prognostic value of surrogate markers of wasted ventilation in patients with COVID-19-related ARDS. A total of 927 consecutive patients admitted with COVID-19-related ARDS were included in this study. Estimations of wasted ventilation such as the estimated dead space fraction (by Harris-Benedict and direct method) and ventilatory ratio were significantly higher in non-survivors than survivors at baseline and during the following days of mechanical ventilation (p < 0. 001). The end-tidal-to-arterial PCO ratio was lower in non-survivors than in survivors (p < 0. 001). As ARDS severity increased, mortality increased with successive tertiles of dead space fraction by Harris-Benedict and by direct estimation, and with an increase in the VR. The same trend was observed with decreased levels in the tertiles for the end-tidal-to-arterial PCO ratio. After adjustment for a base risk model that included chronic comorbidities and ventilation- and oxygenation-parameters, none of the dead space estimates measured at the start of ventilation or the following days were significantly associated with 28-day mortality. There is significant impairment of ventilation in the early course of COVID-19-related ARDS but quantification of this impairment does not add prognostic information when added to a baseline risk model. Trial registration : ISRCTN04346342. Registered 15 April 2020. Retrospectively registered. The online version contains supplementary material available at 10. 1186/s13054-021-03570-0.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Acute respiratory distress syndrome ; ARDS ; Respiratory dead space ; Dead space ; Ventilatory ratio ; COVID-19 ; Mortality ; Prognostication
Published in:	Critical Care, Vol. 25 (may 2021) , ISSN 1466-609X

DOI: 10.1186/s13054-021-03570-0
PMID: 34001222

13 p, 2.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
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