Clinical features, diagnosis, and survival analysis of dogs with glioma
José-López, Roberto (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Gutierrez-Quintana, Rodrigo (University of Glasgow. School of Veterinary Medicine)
de la Fuente, Cristian (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Manzanilla, Edgar G. (The Irish Food and Agriculture Authority)
Suñol, Anna (University of Edinburgh. Royal School of Veterinary Studies)
Pi Castro, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Añor Torres, Sònia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Fernández-Flores, Francisco (University of Liverpool. Institute of Veterinary Science)
Ricci, Emanuele (University of Liverpool. Institute of Veterinary Science)
Marioni-Henry, Katia (University of Edinburgh. Royal School of Veterinary Studies)
Mascort, Joan (ARS Veterinaria)
Matiasek, Lara A. (Anicura Small Animal Clinic)
Matiasek, Kaspar (Ludwig-Maximilians-Universitaet. Centre for Clinical Veterinary Medicine)
Brennan, Paul M. (University of Edinburgh. Centre for Clinical Brain Sciences)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Date:	2021
Abstract:	Gliomas in dogs remain poorly understood. To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification. Ninety-one dogs with histopathological diagnosis of glioma. Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme. No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P =. 03) improved median survival time (84 days; 95% confidence interval [CI], 45-190) compared to palliative treatment (26 days; 95% CI, 11-54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1-weighted hypointensity compared to astrocytomas (odds ratio [OR], 42. 5; 95% CI, 2. 42-744. 97; P =. 04; OR, 45. 5; 95% CI, 5. 78-333. 33; P < . 001, respectively) and undefined gliomas (OR, 84; 95% CI, 3. 43-999. 99; P =. 02; OR, 32. 3; 95% CI, 2. 51-500. 00; P =. 008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7. 47; 95% CI, 1. 03-53. 95; P =. 049). Tumor spread to neighboring brain structures was associated with high-grade glioma (OR, 6. 02; 95% CI, 1. 06-34. 48; P =. 04). Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Astrocytoma ; Dog ; Magnetic resonance imaging ; Oligodendroglioma ; Prognosis ; Tumor grade ; Undefined glioma
Published in:	Journal of Veterinary Internal Medicine, Vol. 35 (june 2021) , p. 1902-1917, ISSN 1939-1676

DOI: 10.1111/jvim.16199
PMID: 34117807

17 p, 2.7 MB

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