High stability of the epigenome in Drosophila interspecific hybrids
Bodelon de Frutos, Alejandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Fablet, Marie (Université Claude Bernard Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
Veber, Philippe (Université Claude Bernard Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
Vieira, Cristina (Université Claude Bernard Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
García Guerreiro, María Pilar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date:	2022
Abstract:	Interspecific hybridization is often seen as a genomic stress that may lead to new gene expression patterns and deregulation of transposable elements (TEs). The understanding of expression changes in hybrids compared with parental species is essential to disentangle their putative role in speciation processes. However, to date we ignore the detailed mechanisms involved in genomic deregulation in hybrids. We studied the ovarian transcriptome and epigenome of the Drosophila buzzatii and Drosophila koepferae species together with their F hybrid females. We found a trend toward underexpression of genes and TE families in hybrids. The epigenome in hybrids was highly similar to the parental epigenomes and showed intermediate histone enrichments between parental species in most cases. Differential gene expression in hybrids was often associated only with changes in H3K4me3 enrichments, whereas differential TE family expression in hybrids may be associated with changes in H3K4me3, H3K9me3, or H3K27me3 enrichments. We identified specific genes and TE families, which their differential expression in comparison with the parental species was explained by their differential chromatin mark combination enrichment. Finally, cis–trans compensatory regulation could also contribute in some way to the hybrid deregulation. This work provides the first study of histone content in Drosophila interspecific hybrids and their effect on gene and TE expression deregulation.
Grants:	Agencia Estatal de Investigación CGL2017-89160P Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1379
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Epigenome ; Drosophila ; Interspecific hybrids ; Deregulation ; Transposable elements ; Histone methylation
Published in:	Genome biology and evolution, Vol. 14, Issue 2 (February 2022) , art. evac024, ISSN 1759-6653

DOI: 10.1093/gbe/evac024
PMID: 35143649

20 p, 1.4 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles