Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults
Redondo-Camós, María (Universitat Autònoma de Barcelona. Departament de Medicina)
Cattaneo, Gabriele (Universitat Autònoma de Barcelona. Departament de Medicina)
Perellón-Alfonso, Ruben (Universitat Autònoma de Barcelona. Departament de Medicina)
Alviarez-Schulze, Vanessa (Universitat Autònoma de Barcelona. Departament de Medicina)
Morris, Timothy P. (Northeastern University)
Solana-Sánchez, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
España-Irla, Goretti (Universitat Autònoma de Barcelona. Departament de Medicina)
Delgado-Gallén, Selma (Universitat Autònoma de Barcelona. Departament de Medicina)
Pachón-García, Catherine (Universitat Autònoma de Barcelona. Departament de Medicina)
Albu, Sergiu (Universitat Autònoma de Barcelona. Departament de Medicina)
Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases)
Tormos, Josep M. (Universitat Autònoma de Barcelona. Departament de Medicina)
Pascual Leone, Álvaro (Department of Neurology, Harvard Medical School)
Bartrés-Faz, David (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2022
Resum:	The prefrontal cortex (PFC) plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography (TMS-EEG) is altered in pathological conditions, and it may also be a marker of cognitive status in middle-aged adults. In this study, we investigated the associations between cognitive measures and TMS evoked EEG reactivity and explored whether the effects of this relationship were related to neurofilament light chain levels (NfL), a marker of neuroaxonal damage. Fifty two healthy middle-aged adults (41-65 years) from the Barcelona Brain Health Initiative cohort underwent TMS-EEG, a comprehensive neuropsychological assessment, and a blood test for NfL levels. Global and Local Mean-Field Power (GMFP/LMFP), two measures of cortical reactivity, were quantified after left prefrontal cortex (L-PFC) stimulation, and cognition was set as the outcome of the regression analysis. The left inferior parietal lobe (L-IPL) was used as a control stimulation condition. Local reactivity was significantly associated with working memory and reasoning only after L-PFC stimulation. No associations were found between NfL and cognition. These specific associations were independent of the status of neuroaxonal damage indexed by the NfL biomarker and remained after adjusting for age, biological sex, and education. Our results demonstrate that TMS evoked EEG reactivity at the L-PFC, but not the L-IPL, is related to the cognitive status of middle-aged individuals and independent of NfL levels, and may become a valuable biomarker of frontal lobe-associated cognitive function.
Ajuts:	Ministerio de Ciencia, Innovación y Universidades RTI2018-095181-B-C21 "la Caixa" Foundation LCF/BQ/DI19/11730050 Fundació la Marató de TV3 ADSF-21-831381-C European Commission. Horizon 2020 777107
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Transcranial magnetic stimulation (TMS) ; Electroencephalography ; TMS-EEG ; Cortical reactivity ; Prefrontal cortex (PFC) ; Cognition
Publicat a:	Frontiers in psychology, Vol. 13 (february 2022) , ISSN 1664-1078

DOI: 10.3389/fpsyg.2022.813444
PMID: 35222201

10 p, 1.0 MB

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