Daptomycin versus Glycopeptides for the Treatment of Enterococcus faecium Bacteraemia : A Cohort Study
Echeverría-Esnal, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques)
Sorlí, Luisa (Hospital del Mar (Barcelona, Catalunya))
Prim, Núria (Laboratori de Referència de Catalunya (Barcelona))
Martin-Ontiyuelo, Clara (Hospital del Mar (Barcelona, Catalunya))
Horcajada, Juan Pablo (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Grau, Santiago (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Fecha:	2021
Resumen:	Background: Ampicillin resistant and glycopeptide susceptible Enterococcus faecium bloodstream infection (GSEF-BSI) incidence has risen. However, the treatment of choice remains unknown. Daptomycin use for the treatment of enterococcal infections has increased, despite effectiveness and safety concerns. The objective was to compare the effectiveness and safety of daptomycin and glycopeptides in the treatment of GSEF-BSI. Methods: This was a single-centre, retrospective observational cohort study performed at Hospital del Mar (Barcelona, Spain), from January 2006-May 2018. The primary outcome was clinical cure at the end of the therapy, and secondary outcomes included 14-day, 30-day, in-hospital mortality, and length of stay. Results: From a total of 192 patients with GSEF-BSI, 54 (28. 1%) were treated with glycopeptides and 17 (8. 9%) with daptomycin. Patients treated with daptomycin presented a lower clinical cure than patients treated with glycopeptides (58. 8% vs. 83. 3%, RR 0. 416 (95% CI 0. 189-0. 915)). After controlling for confounding variables by means of multivariate analysis the significative difference was confirmed (aOR 4. 313, 95% CI, 1. 053-17. 660). The need for treatment discontinuation due to adverse events was similar. Conclusions: Patients with GSEF-BSI treated with glycopeptides showed a higher clinical cure than those treated with daptomycin.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Enterococcus faecium ; Bloodstream infection ; Bacteraemia ; Daptomycin ; Glycopeptides ; Vancomycin
Publicado en:	Antibiotics, Vol. 10 (june 2021) , ISSN 2079-6382

DOI: 10.3390/antibiotics10060716
PMID: 34198646

13 p, 556.7 KB

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