guest ::
| Home > Articles > Published articles > Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder |
| Home > Articles > Published articles > Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder |
(Universidad de Málaga) (Universitat Autònoma de Barcelona. Departament de Medicina) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)| Date: | 2021 |
| Abstract: | Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = − 0. 233, p < 0. 001) but not in the patients with MDD. G-CSF concentrations were lower in patients with SUD than in controls (p < 0. 05), specifically in the cocaine subgroup (p < 0. 05). Patients with SUD and comorbid MDD had lower G-CSF concentrations than patients with SUD but not comorbid MDD or controls (p < 0. 05). In contrast, patients with MDD but not SUD showed no differences compared with their controls. The negative association between G-CSF concentrations and age in the sample was not observed in patients with MDD. G-CSF concentrations were decreased in patients with SUD and comorbid MDD but not in patients with MDD. Therefore, G-CSF may be useful to improve the stratification of patients with dual diagnosis seeking treatment. Further investigation is needed to explore the impact of sex and type of drug on the expression of G-CSF. |
| Grants: | Instituto de Salud Carlos III RD16/0017/001 Ministerio de Economía y Competitividad RD16/0017/0003 Instituto de Salud Carlos III PI17/02026 Instituto de Salud Carlos III PI19/00886 Instituto de Salud Carlos III PI19/01577 Instituto de Salud Carlos III PI20/0883 Instituto de Salud Carlos III CD19/00019 Instituto de Salud Carlos III CPII19/00022 Instituto de Salud Carlos III CPII19/00031 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Molecular biology ; Biomarkers |
| Published in: | Scientific reports, Vol. 11 (july 2021) , ISSN 2045-2322 |
