Tracing the Primordial Chemical Life of Glycine : a Review from Quantum Chemical Simulations
Rimola Gibert, Albert (Universitat Autònoma de Barcelona. Departament de Química)
Balucani, Nadia (Università di Perugia)
Ceccarelli, Cecilia (Université Grenoble Alpes)
Ugliengo, Piero (Università degli Studi di Torino)

Data:	2022
Resum:	Glycine (Gly), NHCHCOOH, is the simplest amino acid. Although it has not been directly detected in the interstellar gas-phase medium, it has been identified in comets and meteorites, and its synthesis in these environments has been simulated in terrestrial laboratory experiments. Likewise, condensation of Gly to form peptides in scenarios resembling those present in a primordial Earth has been demonstrated experimentally. Thus, Gly is a paradigmatic system for biomolecular building blocks to investigate how they can be synthesized in astrophysical environments, transported and delivered by fragments of asteroids (meteorites, once they land on Earth) and comets (interplanetary dust particles that land on Earth) to the primitive Earth, and there react to form biopolymers as a step towards the emergence of life. Quantum chemical investigations addressing these Gly-related events have been performed, providing fundamental atomic-scale information and quantitative energetic data. However, they are spread in the literature and difficult to harmonize in a consistent way due to different computational chemistry methodologies and model systems. This review aims to collect the work done so far to characterize, at a quantum mechanical level, the chemical life of Gly, i. e. , from its synthesis in the interstellar medium up to its polymerization on Earth.
Ajuts:	European Commission 865657 European Commission 741002 European Commission 811312 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1323
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Astrochemistry ; Prebiotic chemistry ; Interstellar grains ; Primitive Earth ; Computational chemistry ; Surface modelling ; Potential energy surfaces ; Metadynamics
Publicat a:	International journal of molecular sciences, Vol. 23 Núm. 8 (April 2022) , art. 4252, ISSN 1422-0067

DOI: 10.3390/ijms23084252
PMID: 35457069

36 p, 3.3 MB

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