Determinants of blood eosinophil levels in the general population and patients with COPD : a population-based, epidemiological study
Miravitlles, Marc (Hospital Universitari Vall d'Hebron)
Soler-Cataluña, Juan José (Universidad de La Laguna)
Soriano, Joan B.. (Universidad Autónoma de Madrid)
García-Rio, Francisco (Hospital Universitario La Paz (Madrid))
de Lucas, Pilar (Hospital General Universitario Gregorio Marañón)
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Casanova, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Rodríguez González-Moro, José Miguel (Universidad de Alcalá)
Sánchez-Herrero, M. Guadalupe (GSK, Tres Cantos)
Ancochea, Julio (Universidad Autónoma de Madrid)
Cosio, Borja G.. (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil count (BEC) in individuals with and without COPD. EPISCAN II is a multicentre, cross-sectional, population-based epidemiological study aimed at investigating the prevalence and determinants of COPD in Spain. Study subjects were randomly selected from the general population, and COPD was defined by a post-bronchodilator FEV/FVC < 0. 7. For the pre-specified outcomes related to BEC, the first 35 COPD and 35 non-COPD subjects were consecutively recruited in 12 of the participating centres with the objective of analysing 400 individuals in each group. Baseline BEC and its association with demographic, clinical and functional variables were analysed. A total of 326 COPD and 399 non-COPD subjects were included in the analysis. The mean age (standard deviation [SD]) was 63. 2 years (11. 0), 46. 3% were male, and 27. 6% were active smokers. BEC was significantly higher in individuals with COPD [192 cells/μL (SD: 125) vs. 160 cells/μL (SD: 114); p = 0. 0003]. In a stepwise multivariate model, being male, active smoker and having a previous diagnosis of asthma were independently associated with having a higher BEC. This population-based study estimated the distribution of eosinophils in the healthy adult population and concluded that COPD patients have a significantly higher BEC. Male sex, active smoking and concomitant asthma were significantly associated with a higher BEC.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Epidemiology ; Computed tomography ; Imaging population ; Biomarkers
Published in:	Respiratory Research, Vol. 23 (march 2022) , ISSN 1465-993X

DOI: 10.1186/s12931-022-01965-3
PMID: 35248041

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