Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis
Román, E. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Poca Pastor, María Antonia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Amorós-Figueras, Gerard (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Rosell-Ferrer, J. (Universitat Politècnica de Catalunya)
Gely, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Nieto Sáchica, Juan Camilo (Institut d'Investigació Biomèdica Sant Pau)
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Urgell, Eulàlia (Institut d'Investigació Biomèdica Sant Pau)
Ferrero-Gregori, A. (Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO))
Alvarado-Tapias, Edilmar (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Cuyàs, Berta (Institut d'Investigació Biomèdica Sant Pau)
Hernández, Elvira (Universitat Autònoma de Barcelona)
Santesmases Masana, Rosalia (Universitat Autònoma de Barcelona)
Guarner-Argente, Carlos (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Escorsell, Àngels (Institut d'Investigació Biomèdica Sant Pau)
Soriano, G.. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)

Date:	2021
Abstract:	The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in these patients, but data are scarce. The aim was to analyse the prognostic value of the phase angle to predict clinically relevant events such as hospitalisation, falls, and mortality in patients with cirrhosis. Outpatients with cirrhosis were consecutively included and the phase angle was determined by electrical bioimpedance. Patients were prospectively followed to determine the incidence of hospitalisations, falls, and mortality. One hundred patients were included. Patients with phase angle ≤ 4. 6° (n = 31) showed a higher probability of hospitalisation (35% vs 11%, p = 0. 003), falls (41% vs 11%, p = 0. 001) and mortality (26% vs 3%, p = 0. 001) at 2-year follow-up than patients with PA > 4. 6° (n = 69). In the multivariable analysis, the phase angle and MELD-Na were independent predictive factors of hospitalisation and mortality. Phase angle was the only predictive factor for falls. In conclusion, the phase angle showed to be a predictive marker for hospitalisation, falls, and mortality in outpatients with cirrhosis.
Grants:	Instituto de Salud Carlos III PI12/00629
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Accidental Falls ; Aged ; Body Composition ; Electric Impedance ; Female ; Hospitalization ; Humans ; Liver Cirrhosis ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis
Published in:	Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 20415, ISSN 2045-2322

DOI: 10.1038/s41598-021-99199-8
PMID: 34650096

11 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles