Zika vector competence data reveals risks of outbreaks : the contribution of the European ZIKAlliance project
Obadia, Thomas (Université Paris Cité. Infectious Disease Epidemiology and Analytics)
Gutierrez-Bugallo, Gladys (Institut Pasteur of Guadeloupe. Unit Transmission Reservoir and Pathogens Diversity)
Duong, Veasna (Institut Pasteur du Cambodge. Virology Unit)
Núñez García, Ana Isabel (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Fernandes, Rosilainy S. (Instituto Oswaldo Cruz. Laboratorio de Mosquitos Transmissores de Hematozoarios)
Kamgang, Basile (Centre for Research in Infectious Diseases. Department of Medical Entomology)
Hery, Liza (Institut Pasteur of Guadeloupe. Unit Transmission Reservoir and Pathogens Diversity)
Gomard, Yann (UMR PIMIT)
Abbo, Sandra R. (Wageningen University. Laboratory of Virology)
Jiolle, Davy (IRD, MIVEGEC, University of Montpellier)
Glavinic, Uros (University of Zürich. National Centre for Vector Entomology)
Dupont-Rouzeyrol, Myrielle (Institut Pasteur de Nouvelle-Calédonie)
Atyame, Célestine M. (UMR PIMIT)
Pocquet, Nicolas (Institut Pasteur de Nouvelle-Calédonie)
Boyer, Sébastien (Institut Pasteur du Cambodge. Medical Entomology Unit)
Dauga, Catherine (Université Paris Cité. Institut Pasteur)
Vazeille, Marie (Université Paris Cité. Institut Pasteur)
Yébakima, André (VECCOTRA)
White, Michael T. (Université Paris Cité. Institut Pasteur)
Koenraadt, Constantianus J. M. (Wageningen University & Research. Laboratory of Entomology)
Mavingui, Patrick (UMR PIMIT)
Vega-Rua, Anubis (Institut Pasteur of Guadeloupe. Unit Transmission Reservoir and Pathogens Diversity)
Veronesi, Eva (University of Zürich. National Centre for Vector Entomology, Institute of Parasitology)
Pijlman, Gorben P. (Wageningen University. Laboratory of Virology)
Paupy, Christophe (University of Montpellier)
Busquets, Núria (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Lourenço-de-Oliveira, Ricardo (Instituto Oswaldo Cruz. aboratorio de Mosquitos Transmissores de Hematozoarios)
De Lamballerie, Xavier (Aix Marseille Université. Unité des Virus Emergents)
Failloux, Anna-Bella (Université Paris Cité. Institut Pasteur)

Date:	2022
Abstract:	First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus, both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika. Zika virus (ZIKV), the causative agent of virus-induced brain damage in newborns, is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus. Here, Obadia et al. characterize ZIKV vector competence of 50 mosquito populations from six species collected in 12 different countries to inform about epidemic risk. They find that African ZIKV strain shows higher transmission efficiency compared to American and Asian ZIKV strains and that Ae. aegypti mosquitoes have highest susceptibility to infections, while Culex mosquitoes are largely non-susceptible.
Grants:	European Commission. Horizon 2020 734548
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Virus-host interactions ; Entomology
Published in:	Nature communications, Vol. 13 (august 2022) , ISSN 2041-1723

DOI: 10.1038/s41467-022-32234-y
PMID: 35918360

8 p, 1.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Articles > Research articles
Articles > Published articles