Intercontinental Gut Microbiome Variances in IBD
Mayorga, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Serrano-Gómez, Gerard (Hospital Universitari Vall d'Hebron)
Xie, Zixuan (Universitat Autònoma de Barcelona. Departament de Medicina)
Borruel, Natalia (Hospital Universitari Vall d'Hebron)
Manichanh, Chaysavanh (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2022
Resum:	The development of biomarkers for inflammatory bowel disease (IBD) diagnosis would be relevant in a generalized context. However, intercontinental investigation on these microbial biomarkers remains scarce. We examined taxonomic microbiome variations in IBD using published DNA shotgun metagenomic data. For this purpose, we used sequenced data from our previous Spanish Crohn's disease (CD) and ulcerative colitis (UC) cohort, downloaded sequence data from a Chinese CD cohort, and downloaded taxonomic and functional profiling tables from a USA CD and UC cohort. At the global level, geographical location and disease phenotype were the main explanatory covariates of microbiome variations. In healthy controls (HC) and UC, geography turned out to be the most important factor, while disease intestinal location was the most important one in CD. Disease severity correlated with lower alpha-diversity in UC but not in CD. Across geography, alpha-diversity was significantly different independently of health status, except for CD. Despite recruitment from different countries and with different disease severity scores, CD patients may harbor a very similar microbial taxonomic profile. Our study pointed out that geographic location, disease activity status, and other environmental factors are important contributing factors in microbiota changes in IBD. We therefore strongly recommend taking these factors into consideration for future IBD studies to obtain globally valid and reproducible biomarkers.
Ajuts:	European Commission. Horizon 2020 812969 Instituto de Salud Carlos III PI17/00614 Instituto de Salud Carlos III PI20/00130
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Microbiome ; IBD ; Geography
Publicat a:	International journal of molecular sciences, Vol. 23 (september 2022) , ISSN 1422-0067

DOI: 10.3390/ijms231810868
PMID: 36142786

15 p, 2.2 MB

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