Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI : a study of 379 individuals
Chino, Brenda (Universitat Autònoma de Barcelona. Institut de Neurociències)
Cuesta, Pablo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Pacios, Javier (Universidad Complutense de Madrid. Departamento de Psicología Experimental)
de Frutos-Lucas, Jaisalmer (Centro de Investigación Nebrija en Cognición (CINC). Universidad de Nebrija)
Torres-Simón, Lucía (Universidad Complutense de Madrid. Departamento de Psicología Experimental)
Doval, Sandra (Universidad Complutense de Madrid. Departamento de Psicología Experimental)
Marcos, Alberto (Hospital Clínico San Carlos (Madrid))
Bruña, Ricardo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Maestú, Fernando (Universidad Complutense de Madrid. Departamento de Psicología Experimental)

Data:	2023
Resum:	Delayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer's disease (AD). Changes in brain functional connectivity (FC) could accompany this decline in the DR performance even in a resting state condition from the preclinical stages to the diagnosis of AD itself, so the characterization of the relationship between the two phenomena has attracted increasing interest. Another aspect to contemplate is the potential moderator role of the APOE genotype in this association, considering the evidence about their implication for the disease. 379 subjects (118 mild cognitive impairment (MCI) and 261 cognitively intact (CI) individuals) underwent an extensive evaluation, including MEG recording. Applying cluster-based permutation test, we identified a cluster of differences in FC and studied which connections drove such an effect in DR. The moderation effect of APOE genotype between FC results and delayed recall was evaluated too. Higher FC in beta band in the right occipital region is associated with lower DR scores in both groups. A significant anteroposterior link emerged in the seed-based analysis with higher values in MCI. Moreover, APOE genotype appeared as a moderator between beta FC and DR performance only in the CI group. An increased beta FC in the anteroposterior brain region appears to be associated with lower memory performance in MCI. This finding could help discriminate the pattern of the progression of healthy aging to MCI and the relation between resting state and memory performance.
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Delayed recall ; MCI ; Cognitively normal ; Functional connectivity ; MEG
Publicat a:	GeroScience, Vol. 45 Num.1 (feb. 2023) , ISSN 2509-2723

DOI: 10.1007/s11357-022-00656-7
PMID: 36109436

13 p, 2.2 MB

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